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Volume 33 Issue 11, Nov 2023

This cover portrays a flowing river, symbolizing the aging of a mother, surrounded by jujube and lotus plants. The seeds of these plants, standing as symbols of having many children, are traditionally given as gifts to newlyweds in Chinese culture to bestow blessings of fertility. Within the river, there are mitochondria undergoing shifts from tubular to donut-shaped structures as the mother ages. These mitochondria, inherited by the offspring, have enduring impacts on their trait formations. See page 821–834 by Runshuai Zhang et al. for details.

RESEARCH HIGHLIGHTS

RHIMoving fibrils of death

Bart Tummers
https://doi.org/10.1038/s41422-023-00875-3
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Lysine metabolism at the nexus of crotonylation and tumor immunity

Fangchao Wei, Jason W. Locasale
https://doi.org/10.1038/s41422-023-00841-z
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How CHKing ROS signaling preserves genomic integrity

Annapoorna Venkatachalam, Scott H. Kaufmann
https://doi.org/10.1038/s41422-023-00840-0
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Accelerated transcriptional elongation during aging impairs longevity

Alexander Tyshkovskiy, Sirui Zhang, Vadim N. Gladyshev
https://doi.org/10.1038/s41422-023-00829-9
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GPCRs and β-arrestins — an on-off relationship

Alex R. B. Thomsen
https://doi.org/10.1038/s41422-023-00838-8
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ORIGINAL ARTICLES

Maternal aging increases offspring adult body size via transmission of donut-shaped mitochondria

Runshuai Zhang, Jinan Fang, Ting Qi, Shihao Zhu, Luxia Yao, Guicun Fang, Yunsheng Li, Xiao Zang, Weina Xu, Wanyu Hao, Shouye Liu, Dan Yang, Di Chen, Jian Yang, Xianjue Ma, Lianfeng Wu
https://doi.org/10.1038/s41422-023-00854-8
Full Text | PDF | Abstract | Open Access


Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate

Yu-Qing Wu, Chen-Song Zhang, Jinye Xiong, Dong-Qi Cai, Chen-Zhe Wang, Yu Wang, Yan-Hui Liu, Yiming Li, Jian Wu, Jianfeng Wu, Bin Lan, Xuefeng Wang, Siwei Chen, Xianglei Cao, Xiaoyan Wei, Hui-Hui Hu, Huiling Guo, Yaxin Yu, Shu-Yong Lin, Hai-Long Piao, Jianyin Zhou, Sheng-Cai Lin
https://doi.org/10.1038/s41422-023-00874-4
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HSPA8 acts as an amyloidase to suppress necroptosis by inhibiting and reversing functional amyloid formation

Erpeng Wu, Wenyan He, Chenlu Wu, Zhangcheng Chen, Shijie Zhou, Xialian Wu, Zhiheng Hu, Kelong Jia, Jiasong Pan, Limin Wang, Jie Qin, Dan Liu, Junxia Lu, Huayi Wang, Jixi Li, Sheng Wang, Liming Sun
https://doi.org/10.1038/s41422-023-00859-3
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Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles

Yunyang Zhang, Xiaomeng Liang, Sha Luo, Yan Chen, Yu Li, Chengying Ma, Ningning Li, Ning Gao
https://doi.org/10.1038/s41422-023-00853-9
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LETTERS TO THE EDITOR

scNanoCOOL-seq: a long-read single-cell sequencing method for multi-omics profiling within individual cells

Jianli Lin, Xiaohui Xue, Yan Wang, Yuan Zhou, Jian Wu, Haoling Xie, Mengya Liu, Lu Wen, Fuchou Tang
https://doi.org/10.1038/s41422-023-00873-5
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Platelet and myeloid lineage biases of transplanted single perinatal mouse hematopoietic stem cells

Karin Belander Strålin, Joana Carrelha, Axel Winroth, Christoph Ziegenhain, Michael Hagemann-Jensen, Laura M. Kettyle, Amy Hillen, Kari Högstrand, Ellen Markljung, Francesca Grasso, Masafumi Seki, Stefania Mazzi, Yiran Meng, Bishan Wu, Edwin Chari, Madeleine Lehander, Rickard Sandberg, Petter S. Woll, Sten Eirik W. Jacobsen
https://doi.org/10.1038/s41422-023-00866-4
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Development of a highly-efficient erythrocyte-drug covalent conjugation platform and its use in treating thrombotic disorders

Yanjie Huang, Xiaoqian Nie, Xuewen Liu, Yuehua Liu, Huifei Yu, Xiaofei Gao
https://doi.org/10.1038/s41422-023-00868-2
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