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Table of Contents

Volume 33 Issue 10, Oct 2023

Nüwa is a mother godness in Chinese culture who molded humans with yellow clay. The clay models show the 46 chromosomes in each cell of human body. A complete genome of a male Han Chinese with all 46 chromosomes assembled at telomere-to-telomere level is presented. See page 745–761 by Chentao Yang et al. for details. The image is credited to Cheng Guo and Huifang Xiao.

RESEARCH HIGHLIGHTS

Steering G protein activation by mGlu heterodimer

Guillaume Lebon
https://doi.org/10.1038/s41422-023-00843-x
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Studying human embryo development with E-assembloids

Janet Rossant
https://doi.org/10.1038/s41422-023-00863-7
Full Text | PDF | Abstract


CAR T cell design: approaching the elusive AND-gate

Zeguo Zhao, Michel Sadelain
https://doi.org/10.1038/s41422-023-00828-w
Full Text | PDF | Abstract


How “rock-and-roll” solved the cullin supply chain problem

Sheena Faye Garcia, Michele Pagano
https://doi.org/10.1038/s41422-023-00825-z
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Dancing with DNA: AID embraces flexible partners

Jianshu Wang, David G. Schatz
https://doi.org/10.1038/s41422-023-00823-1
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ORIGINAL ARTICLES

The complete and fully-phased diploid genome of a male Han Chinese

Chentao Yang, Yang Zhou, Yanni Song, Dongya Wu, Yan Zeng, Lei Nie, Panhong Liu, Shilong Zhang, Guangji Chen, Jinjin Xu, Hongling Zhou, Long Zhou, Xiaobo Qian, Chenlu Liu, Shangjin Tan, Chengran Zhou, Wei Dai, Mengyang Xu, Yanwei Qi, Xiaobo Wang, Lidong Guo, Guangyi Fan, Aijun Wang, Yuan Deng, Yong Zhang, Jiazheng Jin, Yunqiu He, Chunxue Guo, Guoji Guo, Qing Zhou, Xun Xu, Huanming Yang, Jian Wang, Shuhua Xu, Yafei Mao, Xin Jin, Jue Ruan, Guojie Zhang
https://doi.org/10.1038/s41422-023-00849-5
Full Text | PDF | Abstract | Open Access


Structural insights into mechanisms of Argonaute protein-associated NADase activation in bacterial immunity

Xiaoshen Wang, Xuzichao Li, Guimei Yu, Lingling Zhang, Chendi Zhang, Yong Wang, Fumeng Liao, Yanan Wen, Hang Yin, Xiang Liu, Yong Wei, Zhuang Li, Zengqin Deng, Heng Zhang
https://doi.org/10.1038/s41422-023-00839-7
Full Text | PDF | Abstract | Open Access


A direct spino-cortical circuit bypassing the thalamus modulates nociception

Bing Cai, Dan Wu, Hong Xie, Yan Chen, Huadong Wang, Sen Jin, Yuran Song, Anan Li, Shiqi Huang, Sashuang Wang, Yingjin Lu, Lan Bao, Fuqiang Xu, Hui Gong, Changlin Li, Xu Zhang
https://doi.org/10.1038/s41422-023-00832-0
Full Text | PDF | Abstract | Open Access


Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex

Shuqi Dong, Huadong Li, Meilin Wang, Nadia Rasheed, Binqian Zou, Xijie Gao, Jiali Guan, Weijie Li, Jiale Zhang, Chi Wang, Ningkun Zhou, Xue Shi, Mei Li, Min Zhou, Junfeng Huang, He Li, Ying Zhang, Koon Ho Wong, Xiaofei Zhang, William Chong Hang Chao, Jun He
https://doi.org/10.1038/s41422-023-00869-1
Full Text | PDF | Abstract | Open Access


LETTERS TO THE EDITOR

Plant phytochrome A in the Pr state assembles as an asymmetric dimer

Jiao Wang, Chen Zhou, Zeyuan Guan, Qiang Wang, Jun Zhao, Lixia Wang, Liuqing Zhang, Delin Zhang, Xing Wang Deng, Ling Ma, Ping Yin
https://doi.org/10.1038/s41422-023-00847-7
Full Text | PDF | Abstract


Structural insights into plant phytochrome A as a highly sensitized photoreceptor

Yuxuan Zhang, Xiaoli Lin, Chengying Ma, Jun Zhao, Xiaojin Shang, Zhengdong Wang, Bin Xu, Ning Gao, Xing Wang Deng, Jizong Wang
https://doi.org/10.1038/s41422-023-00858-4
Full Text | PDF | Abstract | Open Access