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Volume 34 Issue 2, Feb 2024

Neural connectome mapping describes how different types of neurons connect with each other and organs in the body. This cartoon (illustrated by Evelyn Xiaoya Zhao) shows a densely-stacked neuron network linked by dendrites and axons, together with nonneuronal cells including glial cells, endothelium, pericytes and many others. A new tissue clearing pipeline, TESOS, is designed to image a complete projection course of individual sensory neurons from mouse digits to the spinal cord. See page 124–139 by Yating Yi et al. for details.

RESEARCH HIGHLIGHTS

Lactylation constrains OXPHOS under hypoxia

Haowen Ren, Di Zhang
https://doi.org/10.1038/s41422-023-00872-6
Full Text | PDF | Abstract


TESOS: an integrated approach for uniform mesoscale imaging

Yu Wang, Li Ye
https://doi.org/10.1038/s41422-023-00888-y
Full Text | PDF | Abstract


An engineered surrogate poly(A) tail to wag translation initiation

Stefan Lohse, Wilfried Weber
https://doi.org/10.1038/s41422-023-00903-2
Full Text | PDF | Abstract


SUS(d6)pending MHC class I peptide presentation for cancer immunoevasion

Devin Dersh, Jonathan W. Yewdell
https://doi.org/10.1038/s41422-023-00882-4
Full Text | PDF | Abstract


Fanzors: Striking expansion of RNA-guided endonucleases to eukaryotes

Hui Yang, Dinshaw J. Patel
https://doi.org/10.1038/s41422-023-00894-0
Full Text | PDF | Abstract


REVIEW ARTICLE

The roles and regulatory mechanisms of TGF-β and BMP signaling in bone and cartilage development, homeostasis and disease

Mengrui Wu, Shali Wu, Wei Chen, Yi-Ping Li
https://doi.org/10.1038/s41422-023-00918-9
Full Text | PDF | Abstract | Open Access


ORIGINAL ARTICLES

Mapping of individual sensory nerve axons from digits to spinal cord with the transparent embedding solvent system

Yating Yi, Youqi Li, Shiwen Zhang, Yi Men, Yuhong Wang, Dian Jing, Jiayi Ding, Qingjie Zhu, Zexi Chen, Xingjun Chen, Jun-Liszt Li, Yilong Wang, Jun Wang, Hanchuan Peng, Li Zhang, Wenjing Luo, Jian Q. Feng, Yongwen He, Woo-Ping Ge, Hu Zhao
https://doi.org/10.1038/s41422-023-00867-3
Full Text | PDF | Abstract | Open Access


LDLR is an entry receptor for Crimean-Congo hemorrhagic fever virus

Zhi-Sheng Xu, Wen-Tian Du, Su-Yun Wang, Mo-Yu Wang, Yi-Ning Yang, Yu-Hui Li, Zhen-Qi Li, Li-Xin Zhao, Yan Yang, Wei-Wei Luo, Yan-Yi Wang
https://doi.org/10.1038/s41422-023-00917-w
Full Text | PDF | Abstract | Open Access


The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex mediating autophagosome–lysosome fusion

Fenglei Jian, Shen Wang, Rui Tian, Yufen Wang, Chuangpeng Li, Yan Li, Shixuan Wang, Chao Fang, Cong Ma, Yueguang Rong
https://doi.org/10.1038/s41422-023-00916-x
Full Text | PDF | Abstract


LETTERS TO THE EDITOR

Structural insights into asymmetric activation of the calcium-sensing receptor–Gq complex

Shenglong Ling, Xianyu Meng, Yuan Zhang, Zhemin Xia, Yingxin Zhou, Fan Yang, Pan Shi, Chaowei Shi, Changlin Tian
https://doi.org/10.1038/s41422-023-00892-2
Full Text | PDF | Abstract


Molecular basis of Spns2-facilitated sphingosine-1-phosphate transport

Bin Pang, Leiye Yu, Tong Li, Haizhan Jiao, Xiaomei Wu, Jinxin Wang, Ruiping He, Yurou Zhang, Juan Wang, Hongli Hu, Wei Dai, Li Chen, Ruobing Ren
https://doi.org/10.1038/s41422-023-00908-x
Full Text | PDF | Abstract | Open Access


Structural basis of Sphingosine-1-phosphate transport via human SPNS2

Yaning Duan1, Nancy C. P. Leong, Jing Zhao, Yu Zhang, Dat T. Nguyen, Hoa T. T. Ha, Na Wang, Ruixue Xia, Zhenmei Xu, Zhengxiong Ma, Yu Qian, Han Yin, Xinyan Zhu, Anqi Zhang, Changyou Guo, Yu Xia, Long N. Nguyen, Yuanzheng He
https://doi.org/10.1038/s41422-023-00913-0
Full Text | PDF | Abstract | Open Access
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