Cell Research

Volume 34 Issue 1, Jan 2024

The image shows the tragic story of the Greek soldier Philippides, who brought the victory message of the battle of Marathon to Athens but died after 26 miles and 385 yards (42.195 km) exhaustive running. In fact, human muscle developed mitochondrial protein lactylation as a preventive mechanism for such disaster. See page 13–30 by Yunzi Mao et al. for details.

RESEARCH HIGHLIGHTS

Rpd3S meets the nucleosome

Michael J. Carrozza, Jerry L. Workman
https://doi.org/10.1038/s41422-023-00899-9
Full Text | PDF | Abstract

Caught in the middle: MARCH5 mediates PD-1-induced IL-2R degradation

Xinghao Wang, Weiping Zou
https://doi.org/10.1038/s41422-023-00902-3
Full Text | PDF | Abstract

Swiss army knife T cell: one T cell many tumor targets

Abdulla Berjis, Deeksha Muthumani, Neil C. Sheppard, Carl H. June
https://doi.org/10.1038/s41422-023-00871-7
Full Text | PDF | Abstract

Chromosomal instability drives immunosuppression and metastatic dissemination

Ilio Vitale, Claudia Galassi, Lorenzo Galluzzi
https://doi.org/10.1038/s41422-023-00876-2
Full Text | PDF | Abstract

Learning human liver biology in humanized mice

Brandon M. Lehrich, Satdarshan P. Monga
https://doi.org/10.1038/s41422-023-00877-1
Full Text | PDF | Abstract

LICOB: a powerful organoid platform for drug discovery

Haojie Jin, Zhen Sun, René Bernards
https://doi.org/10.1038/s41422-023-00878-0
Full Text | PDF | Abstract

ORIGINAL ARTICLES

Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation

Yunzi Mao, Jiaojiao Zhang, Qian Zhou, Xiadi He, Zhifang Zheng, Yun Wei, Kaiqiang Zhou, Yan Lin, Haowen Yu, Haihui Zhang, Yineng Zhou, Pengcheng Lin, Baixing Wu, Yiyuan Yuan, Jianyuan Zhao, Wei Xu, Shimin Zhao
https://doi.org/10.1038/s41422-023-00864-6
Full Text | PDF | Abstract | Open Access

Engineered poly(A)-surrogates for translational regulation and therapeutic biocomputation in mammalian cells

Jiawei Shao, Shichao Li, Xinyuan Qiu, Jian Jiang, Lihang Zhang, Pengli Wang, Yaqing Si, Yuhang Wu, Minghui He, Qiqi Xiong, Liuqi Zhao, Yilin Li, Yuxuan Fan, Mirta Viviani, Yu Fu, Chaohua Wu, Ting Gao, Lingyun Zhu, Martin Fussenegger, Hui Wang, Mingqi Xie
https://doi.org/10.1038/s41422-023-00896-y
Full Text | PDF | Abstract | Open Access

Transport and inhibition mechanism for VMAT2-mediated synaptic vesicle loading of monoamines

Yuwei Wang, Pei Zhang, Yulin Chao, Zhini Zhu, Chuanhui Yang, Zixuan Zhou, Yaohui Li, Yonghui Long, Yuehua Liu, Dianfan Li, Sheng Wang, Qianhui Qu
https://doi.org/10.1038/s41422-023-00906-z
Full Text | PDF | Abstract | Open Access

ZNF689 deficiency promotes intratumor heterogeneity and immunotherapy resistance in triple-negative breast cancer

Li-Ping Ge, Xi Jin, Ding Ma, Zi-Yu Wang, Cheng-Lin Liu, Chao-Zheng Zhou, Shen Zhao, Tian-Jian Yu, Xi-Yu Liu, Gen-Hong Di, Zhi-Ming Shao, Yi-Zhou Jiang
https://doi.org/10.1038/s41422-023-00909-w
Full Text | PDF | Abstract

LETTERS TO THE EDITOR

Structural basis for activation and filamentation of glutaminase

Chen-Jun Guo, Zi-Xuan Wang, Ji-Long Liu
https://doi.org/10.1038/s41422-023-00886-0
Full Text | PDF | Abstract | Open Access

Cryo-EM structures of human SID-1 transmembrane family proteins and implications for their low-pH-dependent RNA transport activity

Le Zheng, Tingting Yang, Hangtian Guo, Chen Qi, Yuchi Lu, Haonan Xiao, Yan Gao, Yue Liu, Yixuan Yang, Mengru Zhou, Henry C. Nguyen, Yun Zhu, Fei Sun, Chen-Yu Zhang, Xiaoyun Ji
https://doi.org/10.1038/s41422-023-00893-1
Full Text | PDF | Abstract | Open Access

Human SIDT1 mediates dsRNA uptake via its phospholipase activity

Cai-Rong Sun, Da Xu, Fengrui Yang, Zhuanghao Hou, Yuyao Luo, Chen-Yu Zhang, Ge Shan, Guangming Huang, Xuebiao Yao, Yuxing Chen, Qiong Li, Cong-Zhao Zhou
https://doi.org/10.1038/s41422-023-00889-x
Full Text | PDF | Abstract

CORRIGENDA

Author Correction: BacFlash signals acid-resistance gene expression in bacteria

Di Wu, Wenfeng Qi, Wei Nie, Zhengyuan Lu, Yongxin Ye, Jinghang Li, Tao Sun, Yufei Zhu, Heping Cheng, Xianhua Wang
https://doi.org/10.1038/s41422-023-00900-5
Full Text | PDF | Abstract