RESEARCH HIGHLIGHTS

Illuminating nucleosome interactions

Silvija Bilokapic, Mario Halic
https://doi.org/10.1038/s41422-024-01019-x
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No pain, no gain — how nociceptors orchestrate tissue repair

Pavel Hanč, Ulrich H. von Andrian
https://doi.org/10.1038/s41422-024-00979-4
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Pyroptosis: palmitoylation regulates GSDMD activation and pore formation

Ella Hartenian, Petr Broz
https://doi.org/10.1038/s41422-024-00988-3
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Tumor microenvironment squeezes out the juice from T cells

Romane Thouenon, Grégory Verdeil
https://doi.org/10.1038/s41422-024-00987-4
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All-in-one Hangzhou Protocol: killing four birds with one stone

Haopeng Wang, Shizhen Qiu, Mohamad Mohty
https://doi.org/10.1038/s41422-024-00983-8
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Illuminating the path to pancreatic cancer

Hiroyuki Kato, Nabeel Bardeesy
https://doi.org/10.1038/s41422-024-00982-9
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ORIGINAL ARTICLES

AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

Mengqi Li, Yu Wang, Xiaoyan Wei, Wei-Feng Cai, Jianfeng Wu, Mingxia Zhu, Yongliang Wang, Yan-Hui Liu, Jinye Xiong, Qi Qu, Yan Chen, Xiao Tian, Luming Yao, Renxiang Xie, Xiaomin Li, Siwei Chen, Xi Huang, Cixiong Zhang, Changchuan Xie, Yaying Wu, Zheni Xu, Baoding Zhang, Bin Jiang, Zhi-Chao Wang, Qinxi Li, Gang Li, Shu-Yong Lin, Li Yu, Hai-Long Piao, Xianming Deng, Jiahuai Han, Chen-Song Zhang, Sheng-Cai Lin
https://doi.org/10.1038/s41422-024-00985-6
Full Text | PDF | Abstract | Open Access

Structural basis for linker histone H5–nucleosome binding and chromatin fiber compaction

Wenyan Li, Jie Hu, Feng Song, Juan Yu, Xin Peng, Shuming Zhang, Lin Wang, Mingli Hu, Jia-Cheng Liu, Yu Wei, Xue Xiao, Yan Li, Dongyu Li, Hui Wang, Bing-Rui Zhou, Linchang Dai, Zongjun Mou, Min Zhou, Haonan Zhang, Zheng Zhou, Huidong Zhang, Yawen Bai, Jin-Qiu Zhou, Wei Li, Guohong Li, Ping Zhu
https://doi.org/10.1038/s41422-024-01009-z
Full Text | PDF | Abstract | Open Access

Structural basis of tethered agonism and G protein coupling of protease-activated receptors

Jia Guo, Yun-Li Zhou, Yixin Yang, Shimeng Guo, Erli You, Xin Xie, Yi Jiang, Chunyou Mao, H. Eric Xu, Yan Zhang
https://doi.org/10.1038/s41422-024-00997-2
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LETTERS TO THE EDITOR

Bitter taste receptor TAS2R14 activation and G protein assembly by an intracellular agonist

Lele Tao, Dongxue Wang, Qingning Yuan, Fenghui Zhao, Yu Zhang, Tianyuan Du, Shiyi Shen, H. Eric Xu, Yi Li, Dehua Yang, Jia Duan
https://doi.org/10.1038/s41422-024-00995-4
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Deletion of V483 in the spike confers evolutionary advantage on SARS-CoV-2 for human adaptation and host-range expansion after a prolonged pandemic

Can Yue, Shuo Liu, Bo Meng, Kaiyue Fan, Sijie Yang, Pan Liu, Qianhui Zhu, Xin Mao, Yuanling Yu, Fei Shao, Peng Wang, Youchun Wang, Ravindra Kumar Gupta, Yunlong Cao, Xiangxi Wang
https://doi.org/10.1038/s41422-024-01000-8
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Molecular insights into the inhibition of proton-activated chloride channel by transfer RNA

Pengliang Chi, Xiang Wang, Jialu Li, Hui Yang, Kaiju Li, Yuqi Zhang, Shiyi Lin, Leiye Yu, Shiqi Liu, Lu Chen, Ruobing Ren, Jianping Wu, Zhuo Huang, Jia Geng, Dong Deng
https://doi.org/10.1038/s41422-024-00993-6
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