Advanced Search

Submit Manuscript

Table of Contents

Volume 34 Issue 12, Dec 2024

This image depicts a story of a powerful AI comet merging in the life science universe. The information in millions of single-cell transcriptomes was distilled to create a large foundation model named GeneCompass, which uses cutting-edge foundation model AI technologies to decipher universal gene regulatory mechanisms and shows tremendous potential for accelerating advancements in life science research.See page 830–845 by Xiaodong Yang et al. for details.

EDITORIAL

Sanofi-Cell Research outstanding paper award of 2023

Cell Research Editorial Team
https://doi.org/10.1038/s41422-024-01056-6
Full Text | PDF | Abstract


RESEARCH HIGHLIGHTS

A cross-species foundation model for single cells

Korbinian Traeuble, Matthias Heinig
https://doi.org/10.1038/s41422-024-01045-9
Full Text | PDF | Abstract


Designing de novo D-protein binders

Haiyan Liu
https://doi.org/10.1038/s41422-024-01029-9
Full Text | PDF | Abstract


Fueling metabolic adaptation: lysosomal AMPK ignites glutaminolysis

Benoit Viollet, Bruno Guigas
https://doi.org/10.1038/s41422-024-01040-0
Full Text | PDF | Abstract


Can dental problems be indicative of clonal hematopoiesis?

Soichi Sano, Kenneth Walsh
https://doi.org/10.1038/s41422-024-01006-2
Full Text | PDF | Abstract


Rejuvenating immunity through a balancing stem cell act

Sten Eirik W. Jacobsen
https://doi.org/10.1038/s41422-024-01005-3
Full Text | PDF | Abstract


Yin and Yang of innate immune cell death

Yaqiu Wang, Thirumala-Devi Kanneganti
https://doi.org/10.1038/s41422-024-01007-1
Full Text | PDF | Abstract


ORIGINAL ARTICLES

GeneCompass: deciphering universal gene regulatory mechanisms with a knowledge-informed cross-species foundation model

Xiaodong Yang, Guole Liu, Guihai Feng, Dechao Bu, Pengfei Wang, Jie Jiang, Shubai Chen, Qinmeng Yang, Hefan Miao, Yiyang Zhang, Zhenpeng Man, Zhongming Liang, Zichen Wang, Yaning Li, Zheng Li, Yana Liu, Yao Tian, Wenhao Liu, Cong Li, Ao Li, Jingxi Dong, Zhilong Hu, Chen Fang, Lina Cui, Zixu Deng, Haiping Jiang, Wentao Cui, Jiahao Zhang, Zhaohui Yang, Handong Li, Xingjian He, Liqun Zhong, Jiaheng Zhou, Zijian Wang, Qingqing Long, Ping Xu, The X-Compass Consortium, Hongmei Wang, Zhen Meng, Xuezhi Wang, Yangang Wang, Yong Wang, Shihua Zhang, Jingtao Guo, Yi Zhao, Yuanchun Zhou, Fei Li, Jing Liu, Yiqiang Chen, Ge Yang, Xin Li
https://doi.org/10.1038/s41422-024-01034-y
Full Text | PDF | Abstract | Open Access


Accurate de novo design of heterochiral protein–protein interactions

Ke Sun, Sicong Li, Bowen Zheng, Yanlei Zhu, Tongyue Wang, Mingfu Liang, Yue Yao, Kairan Zhang, Jizhong Zhang, Hongyong Li, Dongyang Han, Jishen Zheng, Brian Coventry, Longxing Cao, David Baker, Lei Liu, Peilong Lu
https://doi.org/10.1038/s41422-024-01014-2
Full Text | PDF | Abstract | Open Access


Population-wide DNA methylation polymorphisms at single-nucleotide resolution in 207 cotton accessions reveal epigenomic contributions to complex traits

Ting Zhao, Xueying Guan, Yan Hu, Ziqian Zhang, Han Yang, Xiaowen Shi, Jin Han, Huan Mei, Luyao Wang, Lei Shao, Hongyu Wu, Qianqian Chen, Yongyan Zhao, Jiaying Pan, Yupeng Hao, Zeyu Dong, Xuan Long, Qian Deng, Shengjun Zhao, Mengke Zhang, Yumeng Zhu, Xiaowei Ma, Zequan Chen, Yayuan Deng, Zhanfeng Si, Xin Li, Tianzhen Zhang, Fei Gu, Xiaofeng Gu, Lei Fang
https://doi.org/10.1038/s41422-024-01027-x
Full Text | PDF | Abstract | Open Access


LETTERS TO THE EDITOR

The mechanism of bacterial defense system DdmDE from Lactobacillus casei

Pingping Huang, Purui Yan, Lijie Guo, Wenying Fei, Zhaoxing Li, Jingxian Liu, Jianping Kong, Yue Yao, Meiling Lu, Yibei Xiao, Meirong Chen
https://doi.org/10.1038/s41422-024-01042-y
Full Text | PDF | Abstract


Reducing off-target effects of DdCBEs by reversing amino acid charge near DNA interaction sites

Long Xie, Yaqi Cao, Di Li, Mengxue Ma, Danrong Jiao, Hu Feng, Zhenrui Zuo1, Erwei Zuo
https://doi.org/10.1038/s41422-024-01028-w
Full Text | PDF | Abstract | Open Access