RESEARCH HIGHLIGHTS

Targeting an alternative route: autophagy in RAS-driven cancers

Alina Üffing, Eleanor Attridge, Sharon A. Tooze
https://doi.org/10.1038/s41422-025-01127-2
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Decoding NLRP3: Phase separation enters the scene

Niklas A. Schmacke, Veit Hornung
https://doi.org/10.1038/s41422-025-01120-9
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Neural crossroads of pancreatic cancer: how nociceptors drive tumor progression and immune evasion

Carmen Mota Reyes, Helmut Friess, Ihsan Ekin Demir
https://doi.org/10.1038/s41422-025-01124-5
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Orchestrating NTSR1 signaling from the interface

Xianglin Huang, Brian E. Krumm, Bryan L. Roth
https://doi.org/10.1038/s41422-025-01121-8
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Spliceosome-associated quality control

Nikita Sharaev, Jiangfeng Zhao, Wojciech P. Galej
https://doi.org/10.1038/s41422-025-01118-3
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ORIGINAL ARTICLES

Oncogenic RAS induces a distinctive form of non-canonical autophagy mediated by the P38-ULK1-PI4KB axis

Xiaojuan Wang, Shulin Li, Shiyin Lin, Yaping Han, Tong Zhan, Zhiying Huang, Juanjuan Wang, Ying Li, Haiteng Deng, Min Zhang, Du Feng, Liang Ge
https://doi.org/10.1038/s41422-025-01085-9
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Structural basis of stepwise proton sensing-mediated GPCR activation

Xiaolei Yue, Li Peng, Shenhui Liu, Bingjie Zhang, Xiaodan Zhang, Hao Chang, Yuan Pei, Xiaoting Li, Junlin Liu, Wenqing Shui, Lijie Wu, Huji Xu, Zhi-Jie Liu, Tian Hua
https://doi.org/10.1038/s41422-025-01092-w
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Signal-induced NLRP3 phase separation initiates inflammasome activation

Gonglu Zou, Yuluan Tang, Jie Yang, Shuo Fu, Yuheng Li, Xuanyao Ren, Nanhai Zhou, Wenlong Zhao, Juyi Gao, Ziran Ruan, Zhengfan Jiang
https://doi.org/10.1038/s41422-025-01096-6
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Mechanistic insights into RNA cleavage by human Argonaute2–siRNA complex

Zhenzhen Li, Qikui Xu, Yan Zhang, Jing Zhong, Tianxiang Zhang, Junchao Xue, Shuxian Liu, Haishan Gao, Z. Z. Zhao Zhang, Jianping Wu, En-Zhi Shen
https://doi.org/10.1038/s41422-025-01114-7
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LETTERS TO THE EDITOR

Mechanisms of chromatin remodeling by the human Snf2-type ATPase SNF2H

Deepshikha Malik, Ashish Deshmukh, Silvija Bilokapic, Mario Halic
https://doi.org/10.1038/s41422-025-01103-w
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CORRIGENDA

Author Correction: Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes

Xiao-Lei Shi, Yimeng Gao, Yupeng Yan, Hucheng Ma, Lulu Sun, Pengyu Huang, Xuan Ni, Ludi Zhang, Xin Zhao, Haozhen Ren, Dan Hu, Yan Zhou, Feng Tian, Yuan Ji, Xin Cheng, Guoyu Pan, Yi-Tao Ding, Lijian Hui
https://doi.org/10.1038/s41422-025-01108-5
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Author Correction: LKB1 inactivation promotes epigenetic remodeling-induced lineage plasticity and antiandrogen resistance in prostate cancer

Fei Li, Pengfei Dai, Huili Shi, Yajuan Zhang, Juan He, Anuradha Gopalan, Dan Li, Yu Chen, Yarui Du, Guoliang Xu, Weiwei Yang, Chao Liang, Dong Gao
https://doi.org/10.1038/s41422-025-01097-5
Full Text | PDF | Abstract | Open Access