Cell Research

Volume 35 Issue 5, May 2025

In Chapter Two of The Secret Life of Sperm, spermatogenesis unfolds as a chromatin symphony. From the pianist spermatogonial stem cell, melodies spiral into Rimsky-Korsakov’s Scheherazade. SETD1B, under RFX2's baton, etches broad H3K4me3 arcs across chromatin. These golden domains outshine their narrow kin, recruit Pol II, and fine- tune transcriptional timing. Stage by stage, shimmering notes guide the epigenetic choreography that shapes the germ cell’s fate. See page 345–361 by Zhen Lin et al. for details.

EDITORIAL

Grow AI virtual cells: three data pillars and closed-loop learning

Liujia Qian, Zhen Dong, Tiannan Guo
https://doi.org/10.1038/s41422-025-01101-y
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RESEARCH HIGHLIGHTS

Broad H3K4me3 domains orchestrate temporal control of gene expression

Yuka Kitamura, Mengwen Hu, Satoshi H. Namekawa
https://doi.org/10.1038/s41422-025-01104-9
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Mechano-pharmacology of T cell receptor specificity

Panyu Fei, Michael L. Dustin
https://doi.org/10.1038/s41422-025-01105-8
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Identification of a GPCR as a tip link-independent equilibrioceptor

Biyun Zhu, Shao Wei Hu, Yilai Shu
https://doi.org/10.1038/s41422-025-01102-x
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Chemogenetics for sensing antigens

Blake A. Fordyce, Bryan L. Roth
https://doi.org/10.1038/s41422-025-01072-0
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Hangry hairs: intermittent fasting linked to hair loss

Carlos Galvan, William E. Lowry
https://doi.org/10.1038/s41422-025-01082-y
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Encoding immune responses: the moonlighting function of alanyl-tRNA synthetase

Pin Wang, Xiaoyu Hu
https://doi.org/10.1038/s41422-024-01055-7
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REVIEW ARTICLE

Pyroptosis: molecular mechanisms and roles in disease

Petr Broz
https://doi.org/10.1038/s41422-025-01107-6
Full Text | PDF | Abstract | Open Access

ORIGINAL ARTICLES

SETD1B-mediated broad H3K4me3 controls proper temporal patterns of gene expression critical for spermatid development

Zhen Lin, Bowen Rong, Ruitu Lyu, Yuxuan Zheng, Yao Chen, Junyi Yan, Meixia Wu, Xiaogang Gao, Fuchou Tang, Fei Lan, Ming-Han Tong
https://doi.org/10.1038/s41422-025-01080-0
Full Text | PDF | Abstract | Open Access

Nociceptor neurons promote PDAC progression and cancer pain by interaction with cancer-associated fibroblasts and suppression of natural killer cells

Kaiyuan Wang, Bo Ni, Yongjie Xie, Zekun Li, Limei Yuan, Chenyang Meng, Tiansuo Zhao, Song Gao, Chongbiao Huang, Hongwei Wang, Ying Ma, Tianxing Zhou, Yukuan Feng, Antao Chang, Chao Yang, Jun Yu, Wenwen Yu, Fenglin Zang, Yanhui Zhang, Ru-Rong Ji, Xiuchao Wang, Jihui Hao
https://doi.org/10.1038/s41422-025-01098-4
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LETTERS TO THE EDITOR

Transport and inhibition mechanism for human TauT-mediated taurine uptake

Yulin Chao, Zixuan Zhou, Hao Xi, Chuanhui Yang, Tingting Li, Yi-Quan Tang, Yilai Shu, Qian Ba, Jiaxu Hong, Dianfan Li, Qianhui Qu
https://doi.org/10.1038/s41422-025-01076-w
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