RESEARCH HIGHLIGHTS

Leucyl-tRNA synthetase: double duty in amino acid sensing

Raúl V Durán and Michael N Hall
Cell Research (2012) 22:1207-1209. doi: 10.1038/cr.2012.68; published online 24 April 2012
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Early exposure to germs and the Hygiene Hypothesis

Dale T Umetsu
Cell Research (2012) 22:1210-1211. doi:10.1038/cr.2012.65; published online 24 April 2012
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Gating neural development and aging via nuclear pores

Guang-Hui Liu, Mo Li, Jing Qu and Juan Carlos Izpisua Belmonte
Cell Research (2012) 22:1212-1214. doi:10.1038/cr.2012.35; published online 13 March 2012
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Will the real aging Sirtuin please stand up?

Chen-Yu Liao and Brian K Kennedy
Cell Research (2012) 22:1215-1217. doi: 10.1038/cr.2012.62; published online 17 April 2012
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Time is of the essence: microRNAs and age-associated neurodegeneration

Sherry Aw and Stephen M Cohen
Cell Research (2012) 22:1218-1220. doi: 10.1038/cr.2012.59; published online 10 April 2012
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K48-linked ubiquitination and protein degradation regulate 53BP1 recruitment at DNA damage sites

Frédérick A Mallette and Stéphane Richard
Cell Research (2012) 22:1221-1223. doi:10.1038/cr.2012.58; published online 10 April 2012
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CUL4B ubiquitin ligase in mouse development: A model for human X-linked mental retardation syndrome?

Yongchao Zhao and Yi Sun
Cell Research (2012) 22:1224-1226. doi:10.1038/cr.2012.79; published online 15 May 2012
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ORIGINAL ARTICLES

Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies

Michael Steckel, Miriam Molina-Arcas, Britta Weigelt, Michaela Marani, Patricia H Warne, Hanna Kuznetsov, Gavin Kelly, Becky Saunders, Michael Howell
Cell Research (2012) 22:1227-1245. doi:10.1038/cr.2012.82; published online 22 May 2012
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The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation

Hui-Ling Guo, Cixiong Zhang, Qi Liu, Qinxi Li, Guili Lian, Di Wu, Xuebin Li, Wei Zhang, Yuemao Shen, Zhiyun Ye, Shu-Yong L
Cell Research (2012) 22:1246-1257. doi:10.1038/cr.2012.52; published online 3 April 2012
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Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis

Liren Liu, Yan Yin, Yuewei Li, Lisa Prevedel, Elizabeth H Lacy, Liang Ma and Pengbo Zhou
Cell Research (2012) 22:1258-1269. doi:10.1038/cr.2012.48; published online 27 March 2012
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Nudel is crucial for the WAVE complex assembly in vivo by selectively promoting subcomplex stability and formation through direct interactions

Shuang Wu, Li Ma, Yibo Wu, Rong Zeng and Xueliang Zhu
Cell Research (2012) 22:1270-1284. doi:10.1038/cr.2012.47; published online 27 March 2012
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N-methylpurine DNA glycosylase inhibits p53-mediated cell cycle arrest and coordinates with p53 to determine sensitivity to alkylating agents

Shanshan Song, Guichun Xing, Lin Yuan, Jian Wang, Shan Wang, Yuxin Yin, Chunyan Tian, Fuchu He and Lingqiang Zhang
Cell Research (2012) 22:1285-1303. doi:10.1038/cr.2012.107; published online 17 July 2012
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LETTERS TO THE EDITOR

Structural basis for the impact of phosphorylation on the activation of plant receptor-like kinase BAK1

Liming Yan, Yuanyuan Ma, Dan Liu, Xiaochao Wei, Yuna Sun, Xiaoyue Chen, Huadong Zhao, Jingwen Zhou, Zhiyong Wang, Wenqing Shui
Cell Research (2012) 22:1304-1308. doi:10.1038/cr.2012.74; published online 1 May 2012
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