RESEARCH HIGHLIGHTS

A chemical approach to “rewire” neural progenitor cells

Min-Zu Wu, Mo Li, Guang-Hui Liu and Juan Carlos Izpisua Belmonte
10.1038/cr.2014.51
Full Text | PDF | Abstract

'Lnc'-ing enhancers to MYC regulation

Scott T Younger and John L Rinn
10.1038/cr.2014.54
Full Text | PDF | Abstract

The lock-washer: a reconciliation of the RIG-I activation models

Shu Zhu, Ruaidhri Jackson and Richard A Flavell
10.1038/cr.2014.58
Full Text | PDF | Abstract

Possible leap ahead in filovirus therapeutics

Darryl Falzarano and Heinz Feldmann
10.1038/cr.2014.49
Full Text | PDF | Abstract

Recognizing methylated histone variant H3.3 to prevent tumors

Swaminathan Venkatesh and Jerry L Workman
10.1038/cr.2014.50
Full Text | PDF | Abstract

REVIEW

No receptor stands alone: IgG B-cell receptor intrinsic and extrinsic mechanisms contribute to antibody memory

Yinsheng Xu, Liling Xu, Meng Zhao, ChenGuang Xu, Yilin Fan, Susan K Pierce and Wanli Liu
10.1038/cr.2014.65
Full Text | PDF | Abstract | Open Access

ORIGINAL ARTICLES

Generation of neural progenitor cells by chemical cocktails and hypoxia

Lin Cheng, Wenxiang Hu, Binlong Qiu, Jian Zhao, Yongchun Yu, Wuqiang Guan, Min Wang, Wuzhou Yang and Gang Pei
10.1038/cr.2014.32
Full Text | PDF | Abstract | Open Access

Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis

Lan-Tao Gou, Peng Dai, Jian-Hua Yang, Yuanchao Xue, Yun-Ping Hu, Yu Zhou, Jun-Yan Kang, Xin Wang, Hairi Li, Min-Min Hua, Shuang Zhao, Si-Da Hu, Li-Gang Wu, Hui-Juan Shi, Yong Li, Xiang-Dong Fu, Liang-Hu Qu, En-Duo Wang and Mo-Fang Liu
10.1038/cr.2014.41
Full Text | PDF | Abstract | Open Access

Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing

Chang Yu, Jun Yu, Xiaotian Yao, William KK Wu, Youyong Lu, Senwei Tang, Xiangchun Li, Li Bao, Xiaoxing Li, Yong Hou, Renhua Wu, Min Jian, Ruoyan Chen, Fan Zhang, Lixia Xu, Fan Fan, Jun He, Qiaoyi Liang, Hongyi Wang, Xueda Hu, Minghui He, Xiang Zhang, Hancheng Zheng, Qibin Li, Hanjie Wu, Yan Chen, Xu Yang, Shida Zhu, Xun Xu, Huanming Yang, Jian Wang, Xiuqing Zhang, Joseph JY Sung, Yingrui Li and Jun Wang
10.1038/cr.2014.43
Full Text | PDF | Abstract

Structures and mechanism for the design of highly potent glucocorticoids

Yuanzheng He, Wei Yi, Kelly Suino-Powell, X Edward Zhou, W David Tolbert, Xiaobo Tang, Jing Yang, Huaiyu Yang, Jingjing Shi, Li Hou, Hualiang Jiang, Karsten Melcher and H Eric Xu
10.1038/cr.2014.52
Full Text | PDF | Abstract

Specific control of BMP signaling and mesenchymal differentiation by cytoplasmic phosphatase PPM1H

Tao Shen, Chuang Sun, Zhengmao Zhang, Ningyi Xu, Xueyan Duan, Xin-Hua Feng and Xia Lin
doi:10.1038/cr.2014.48
Full Text | PDF | Abstract

CKIP-1 regulates macrophage proliferation by inhibiting TRAF6-mediated Akt activation

Luo Zhang, Yiwu Wang, Fengjun Xiao, Shaoxia Wang, Guichun Xing, Yang Li, Xiushan Yin, Kefeng Lu, Rongfei Wei, Jiao Fan, Yuhan Chen, Tao Li, Ping Xie, Lin Yuan, Lei Song, Lanzhi Ma, Lujing Ding, Fuchu He and Lingqiang Zhang
10.1038/cr.2014.53
Full Text | PDF | Abstract

LETTERS TO THE EDITOR

Structural insights into the TRIM family of ubiquitin E3 ligases

Yang Li, Han Wu, Wei Wu, Wei Zhuo, Weixiao Liu, Yixiao Zhang, Minzhang Cheng, Ye-Guang Chen, Ning Gao, Hongtao Yu, Linfang Wang, Wei Li and Maojun Yang
10.1038/cr.2014.46
Full Text | PDF | Abstract | Open Access

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

Basant Kumar Thakur, Haiying Zhang, Annette Becker, Irina Matei, Yujie Huang, Bruno Costa-Silva, Yan Zheng, Ayuko Hoshino, Helene Brazier, Jenny Xiang, Caitlin Williams, Ruth Rodriguez-Barrueco, Jose M Silva, Weijia Zhang, Stephen Hearn, Olivier Elemento, Navid Paknejad, Katia Manova-Todorova, Karl Welte, Jacqueline Bromberg, Héctor Peinado and David Lyden
doi:10.1038/cr.2014.44
Full Text | PDF | Abstract | Open Access

Production of bioactive ginsenoside compound K in metabolically engineered yeast

Xing Yan, Yun Fan, Wei Wei, Pingping Wang, Qunfang Liu, Yongjun Wei, Lei Zhang, Guoping Zhao, Jianmin Yue and Zhihua Zhou
10.1038/cr.2014.28
Full Text | PDF | Abstract