RESEARCH HIGHLIGHTS

Mediator redefines itself

Nicholas C Sennett and Dylan J Taatjes
10.1038/cr.2014.76
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Notching up vascular regeneration

Bing Zhang and William T Pu
10.1038/cr.2014.68
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piRNAs, master regulators of gene expression

Martine Simonelig
10.1038/cr.2014.78
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Keeping 53BP1 out of focus in mitosis

Rimma Belotserkovskaya and Stephen P Jackson
10.1038/cr.2014.62
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Identifying specific receptors for cargo-mediated autophagy

Megan Goodall and Andrew Thorburn
10.1038/cr.2014.56
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Akt: a new activation mechanism

Yuan Gao, Asad Moten and Hui-Kuan Lin
10.1038/cr.2014.57
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REVIEW

Receptor-mediated mitophagy in yeast and mammalian systems

Lei Liu, Kaori Sakakibara, Quan Chen and Koji Okamoto
10.1038/cr.2014.75
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ORIGINAL ARTICLES

Redefining the modular organization of the core Mediator complex

Xuejuan Wang, Qianqian Sun, Zhenrui Ding, Jinhua Ji, Jianye Wang, Xiao Kong, Jianghong Yang and Gang Cai
10.1038/cr.2014.64
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An epigenomic approach to therapy for tamoxifen-resistant breast cancer

Qin Feng, Zheng Zhang, Martin J Shea, Chad J Creighton, Cristian Coarfa, Susan G Hilsenbeck, Rainer Lanz, Bin He, Lei Wang, Xiaoyong Fu, Agostina Nardone, Yongcheng Song, James Bradner, Nicholas Mitsiades, Constantine S Mitsiades, C Kent Osborne, Rachel Schiff and Bert W O Malley
10.1038/cr.2014.71
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Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells

Makoto Sahara, Emil M Hansson, Oliver Wernet, Kathy O Lui, Daniela Später and Kenneth R Chien
10.1038/cr.2014.59
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Ribosome profiling reveals sequence-independent post-initiation pausing as a signature of translation

Yan Han, Xiangwei Gao, Botao Liu, Ji Wan, Xingqian Zhang and Shu-Bing Qian
10.1038/cr.2014.74
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Atg7 is required for acrosome biogenesis during spermatogenesis in mice

Hongna Wang, Haifeng Wan, Xixia Li, Weixiao Liu, Qi Chen, Yaqing Wang, Lin Yang, Hongmei Tang, Xiujun Zhang, Enkui Duan, Xiaoyang Zhao, Fei Gao and Wei Li
10.1038/cr.2014.70
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Trypanosoma brucei TIF2 suppresses VSG switching by maintaining subtelomere integrity

Sanaa E Jehi, Fan Wu and Bibo Li
10.1038/cr.2014.60
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LETTERS TO THE EDITOR

Heritable/conditional genome editing in C. elegans using a CRISPR-Cas9 feeding system

The Education Ministry Key Laboratory of Cell Proliferation and Differentiation and the State Key Laboratory of Bio-membrane and Membrane Bio-engineering, School of Life Sciences, Peking University, Beijing, China Institute of Molecular Medicine, Peking University, Beijing, China
10.1038/cr.2014.73
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Crystal structure of human BS69 Bromo-ZnF-PWWP reveals its role in H3K36me3 nucleosome binding

Juncheng Wang, Su Qin, Fudong Li, Sai Li, Wei Zhang, Junhui Peng, Zhiyong Zhang, Qingguo Gong, Jihui Wu and Yunyu Shi
10.1038/cr.2014.38
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Labeling native bacterial RNA in live cells

Paul Toran, Irina Smolina, Harry Driscoll, Feng Ding, Yingjie Sun, Charles R Cantor and Natalia E Broude
10.1038/cr.2014.47
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