RESEARCH HIGHLIGHTS

BETs abet Tam-R in ER-positive breast cancer

Prasanna G Alluri, Irfan A Asangani and Arul M Chinnaiyan
10.1038/cr.2014.90
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Targeting Th17 cells in immune diseases

Chen Dong
10.1038/cr.2014.92
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Hallmarks of triple negative breast cancer are emerging at last?

Rosa Bernardi and Luca Gianni
10.1038/cr.2014.61
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Linking SOX10 to a slow-growth resistance phenotype

Gao Zhang and Meenhard Herlyn
10.1038/cr.2014.67
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Regulating the regulator of ROS production

Marcelo G Bonini and Asrar B Malik
10.1038/cr.2014.66
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The soft underbelly of tumor cells

Yufeng Shi, S Kyun Lim and Luis F Parada
10.1038/cr.2014.72
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ORIGINAL ARTICLES

Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation

Benyu Ma, Weipeng Cao, Wenxia Li, Chan Gao, Zhen Qi, Yan Zhao, Jun Du, Hua Xue, Junya Peng, Jun Wen1, Hua Chen, Yuanheng Ning, Lei Huang, Hong Zhang, Xiang Gao, Li Yu and Ye-Guang Chen
10.1038/cr.2014.84
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Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms

Shuang Zhang1,*, Shuangbo Kong1,2,*, Bingyan Wang1, Xiaohong Cheng, Yongjie Chen, Weiwei Wu, Qiang Wang, Junchao Shi, Ying Zhang, Shumin Wang, Jinhua Lu, John P Lydon, Francesco DeMayo, Warren S Pear, Hua Han, Haiyan Lin, Lei Li, Hongmei Wang, Yan-ling Wang, Bing Li, Qi Chen, Enkui Duan and Haibin Wang
10.1038/cr.2014.82
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RNF2 is recruited by WASH to ubiquitinate AMBRA1 leading to downregulation of autophagy

Pengyan Xia, Shuo Wang, Guanling Huang, Ying Du, Pingping Zhu, Man Li and Zusen Fan
10.1038/cr.2014.85
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Regulation of EGFR nanocluster formation by ionic protein-lipid interaction

Ye Wang, Jing Gao, Xingdong Guo, Ti Tong, Xiaoshan Shi, Lunyi Li, Miao Qi, Yajie Wang, Mingjun Cai, Junguang Jiang, Chenqi Xu, Hongbin Ji and Hongda Wang
10.1038/cr.2014.89
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Tom70 serves as a molecular switch to determine pathological cardiac hypertrophy

Jun Li, Man Qi, Changming Li, Dan Shi, Dasheng Zhang, Duanyang Xie, Tianyou Yuan, Jing Feng, Yi Liu, Dandan Liang, Xinran Xu, Jinjin Chen, Liang Xu, Hong Zhang, Jiangchuan Ye, Fei Lv, Jian Huang, Luying Peng and Yi-Han Chen
10.1038/cr.2014.94
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A Smad3 and TTF-1/NKX2-1 complex regulates Smad4-independent gene expression

Kazunobu Isogaya, Daizo Koinuma, Shuichi Tsutsumi, Roy-Akira Saito, Keiji Miyazawa, Hiroyuki Aburatani and Kohei Miyazono
10.1038/cr.2014.97
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LETTERS TO THE EDITOR

Genome-wide identification of CRISPR/Cas9 off-targets in human genome

Jinzhi Duan, Guangqing Lu, Zhan Xie, Mingliang Lou, Jiao Luo, Lei Guo and Yu Zhang
10.1038/cr.2014.87
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Lis1 is required for the expansion of hematopoietic stem cells in the fetal liver

Xufeng Chen, Jiali Zhang, Jingyao Zhao, Haifeng Liu, Xiang Sun, Mujun Zhao and Xiaolong Liu
10.1038/cr.2014.69
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TET-catalyzed 5-methylcytosine hydroxylation is dynamically regulated by metabolites

Hui Yang, Huaipeng Lin, Haiyan Xu, Lei Zhang, Lu Cheng, Bo Wen, Jianyong Shou, Kunliang Guan, Yue Xiong and Dan Ye
10.1038/cr.2014.81
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