RESEARCH HIGHLIGHTS

Inflammasome assembly: The wheels are turning

Petr Broz
10.1038/cr.2015.137
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Detecting hepatocellular carcinoma in blood

Lulu Hu and Chuan He
10.1038/cr.2015.136
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The quest for spatio-temporal control of CAR T cells

Jie Sun and Michel Sadelain
10.1038/cr.2015.131
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RNA editing by ADAR1 marks dsRNA as “self”

Zhou Yu, Taoyong Chen and Xuetao Cao
10.1038/cr.2015.135
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ORIGINAL ARTICLES

Gasdermin D is an executor of pyroptosis and required for interleukin-1β ecretion

Wan-ting He, Haoqiang Wan, Lichen Hu, Pengda Chen, Xin Wang, Zhe Huang, Zhang-Hua Yang, Chuan-Qi Zhong and Jiahuai Han
doi:10.1038/cr.2015.139
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The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1

Carsten Gram Hansen, Yuen Lam Dora Ng, Wai-Ling Macrina Lam, Steven W Plouffe and Kun-Liang Guan
doi:10.1038/cr.2015.140
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MSX2 mediates entry of human pluripotent stem cells into mesendoderm by simultaneously suppressing SOX2 and activating NODAL signaling

Qingqing Wu, Leisheng Zhang, Pei Su, Xiaohua Lei, Xin Liu, Hongtao Wang, Lisha Lu, Yang Bai, Tao Xiong, Dong Li, Zhengmao Zhu, Enkui Duan, Erlie Jiang, Sizhou Feng, Mingzhe Han, Yuanfu Xu, Fei Wang and Jiaxi Zhou
10.1038/cr.2015.118
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Tuberculosis is associated with expansion of a motile, permissive and immunomodulatory CD16⁺ monocyte population via the IL-10/STAT3 axis

Claire Lastrucci, Alan Bénard, Luciana Balboa, Karine Pingris, Shanti Souriant, Renaud Poincloux, Talal Al Saati, Voahangy Rasolofo, Pablo González-Montaner, Sandra Inwentarz, Eduardo Jose Moraña, Ivanela Kondova, Frank AW Verreck, Maria del Carmen Sasiain, Olivier Neyrolles, Isabelle Maridonneau-Parini, Geanncarlo Lugo-Villarino and Céline Cougoule
10.1038/cr.2015.123
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PslG, a self-produced glycosyl hydrolase, triggers biofilm disassembly by disrupting exopolysaccharide matrix

Shan Yu, Tiantian Su, Huijun Wu, Shiheng Liu, Di Wang, Tianhu Zhao, Zengjun Jin, Wenbin Du, Mei-Jun Zhu, Song Lin Chua, Liang Yang, Deyu Zhu, Lichuan Gu and Luyan Z Ma
doi:10.1038/cr.2015.129
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LETTERS TO THE EDITOR

Development of the anterior-posterior axis is a self-organizing process in the absence of maternal cues in the mouse embryo

Ivan Bedzhov, Monika Bialecka, Agata Zielinska, Joanna Kosalka, Francesco Antonica, Amelia J Thompson, Kristian Franze and Magdalena Zernicka-Goetz
10.1038/cr.2015.104
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CRISPR/Cas9-mediated genome engineering of the ferret

Zhaohui Kou, Qian Wu, Xiaochen Kou, Chonghai Yin, Hong Wang, Zhentao Zuo, Yan Zhuo, Antony Chen, Shaorong Gao and Xiaoqun Wang
10.1038/cr.2015.130
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ERRATUM

Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients

Lu Wen, Jingyi Li, Huahu Guo, Xiaomeng Liu, Shengmin Zheng, Dafang Zhang, Weihua Zhu, Jianhui Qu, Limin Guo, Dexiao Du, Xiao Jin, Yuhao Zhang, Yun Gao, Jie Shen, Hao Ge, Fuchou Tang, Yanyi Huang and Jirun Peng
doi:10.1038/cr.2015.141
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