RESEARCH HIGHLIGHTS

Structural insights of mTOR complex 1

Hai-Xin Yuan and Kun-Liang Guan
10.1038/cr.2016.10
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Anti-cancer effects of vitamin C revisited

Jiska van der Reest and Eyal Gottlieb
10.1038/cr.2016.7
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Lupus pathogenesis: role of IgE autoantibodies

Jagadeesh Bayry
10.1038/cr.2016.12
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Arresting supporters: targeting neutrophils in metastasis

Swarnali Acharyya and Joan Massague
10.1038/cr.2016.17
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ORIGINAL ARTICLES

Oocyte-expressed yes-associated protein is a key activator of the early zygotic genome in mouse

Chao Yu, Shu-Yan Ji, Yu-Jiao Dang, Qian-Qian Sha, Yi-Feng Yuan, Jian-Jie Zhou, Li-Ying Yan, Jie Qiao, Fuchou Tang and Heng-Yu Fan
10.1038/cr.2016.20
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The RNA-binding protein Mex3B is a coreceptor of Toll-like receptor 3 in innate antiviral response

Yan Yang, Su-Yun Wang, Zhe-Fu Huang, Hong-Mei Zou, Bing-Ru Yan, Wei-Wei Luo and Yan-Yi Wang
10.1038/cr.2016.16
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Single-cell triple omics sequencing reveals genetic, epigenetic, and transcriptomic heterogeneity in hepatocellular carcinomas

Yu Hou, Huahu Guo, Chen Cao, Xianlong Li, Boqiang Hu, Ping Zhu, Xinglong Wu, Lu Wen, Fuchou Tang, Yanyi Huang and Jirun Peng
10.1038/cr.2016.23
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saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription

Victoria Portnoy, Szu Hua Sharon Lin, Kathy H Li, Alma Burlingame, Zheng-Hui Hu, Hao Li and Long-Cheng Li
10.1038/cr.2016.22
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Cooperative autoinhibition and multi-level activation mechanisms of calcineurin

Sheng-Jie Li, Jue Wang, Lei Ma, Chang Lu, Jie Wang, Jia-Wei Wu and Zhi-Xin Wang
10.1038/cr.2016.14
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Pluripotency-associated miR-290/302 family of microRNAs promote the dismantling of naive pluripotency

Kai-Li Gu, Qiang Zhang, Ying Yan, Ting-Ting Li, Fei-Fei Duan, Jing Hao, Xi-Wen Wang, Ming Shi, Da-Ren Wu, Wen-Ting Guo and Yangming Wang
10.1038/cr2016.2
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The kinase activity of PKR represses inflammasome activity

Howard CH Yim, Die Wang, Liang Yu, Christine L White, Pieter W Faber, Bryan RG Williams and Anthony J Sadler
10.1038/cr.2016.11
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LETTERS TO THE EDITOR

An Ebola virus-encoded microRNA-like fragment serves as a biomarker for early diagnosis of Ebola virus disease

Zeliang Chen, Hongwei Liang, Xi Chen, Yuehua Ke, Zhen Zhou, Mingjuan Yang, Ke Zen, Ruifu Yang, Chao Liu and Chen-Yu Zhang
10.1038/cr.2016.21
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NF-YB1-regulated expression of sucrose transporters in aleurone facilitates sugar loading to rice endosperm

Ai-Ning Bai, Xiao-Duo Lu, Dong-Qi Li, Jin-Xin Liu and Chun-Ming Liu
10.1038/cr.2015.116
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