RESEARCH HIGHLIGHTS

SIRT6, oxidative stress, and aging

Chen-Yu Liao and Brian K Kennedy
10.1038/cr.2016.8
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Master and commander: epigenetic regulation of macrophages

Mihai G Netea and Leo AB Joosten
10.1038/cr.2016.5
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The XEN of reprogramming

Ergin Beyret and Juan Carlos Izpisua Belmonte
10.1038/cr.2016.9
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Organotropic metastasis: role of tumor exosomes

Yang Liu and Xuetao Cao
10.1038/cr.2015.153
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ORIGINAL ARTICLES

The transcriptional regulator network of human inflammatory macrophages is defined by open chromatin

Susanne V Schmidt, Wolfgang Krebs, Thomas Ulas, Jia Xue, Kevin Baßler, Patrick Günther, Anna-Lena Hardt, Hartmut Schultze, Jil Sander, Kathrin Klee, Heidi Theis, Michael Kraut, Marc Beyer and Joachim L Schultze
10.1038/cr.2016.1
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Comprehensive profiling reveals mechanisms of SOX2-mediated cell fate specification in human ESCs and NPCs

Chenlin Zhou, Xiaoqin Yang, Yiyang Sun, Hongyao Yu, Yong Zhang and Ying Jin
10.1038/cr.2016.15
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SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2

Huize Pan, Di Guan, Xiaomeng Liu, Jingyi Li, Lixia Wang, Jun Wu, Junzhi Zhou, Weizhou Zhang, Ruotong Ren, Weiqi Zhang, Ying Li, Jiping Yang, Ying Hao, Tingting Yuan, Guohong Yuan, Hu Wang, Zhenyu Ju, Zhiyong Mao, Jian Li, Jing Qu, Fuchou Tang and Guang-Hui Liu
10.1038/cr.2016.4
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Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes

Xiao-Lei Shi, Yimeng Gao, Yupeng Yan, Hucheng Ma, Lulu Sun, Pengyu Huang, Xuan Ni, Ludi Zhang, Xin Zhao, Haozhen Ren, Dan Hu, Yan Zhou, Feng Tian, Yuan Ji, Xin Cheng, Guoyu Pan, Yi-Tao Ding and Lijian Hui
10.1038/cr.2016.6
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Cross-kingdom inhibition of breast cancer growth by plant miR159

Andrew R Chin, Miranda Y Fong, George Somlo, Jun Wu, Piotr Swiderski, Xiwei Wu and Shizhen Emily Wang
10.1038/cr.2016.13
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Mutation of C. elegans demethylase spr-5 extends transgenerational longevity

Eric Lieberman Greer, Ben Becker, Christian Latza, Adam Antebi and Yang Shi
10.1038/cr.2015.148
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NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin 1

Cheng Zhang, Wen Zhang, Yi Lu, Xiaoyi Yan, Xiumin Yan, Xueliang Zhu, Wei Liu, Yuehong Yang and Tianhua Zhou
10.1038/cr.2015.152
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LETTERS TO THE EDITOR

Casilio: a versatile CRISPR-Cas9-Pumilio hybrid for gene regulation and genomic labeling

Albert W Cheng, Nathaniel Jillette, Phoebe Lee, Dylan Plaskon, Yasuhiro Fujiwara, Wenbo Wang, Aziz Taghbalout and Haoyi Wang
10.1038/cr.2016.3
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Pathway mining-based integration of critical enzyme parts for de novo biosynthesis of steviolglycosides sweetener in Escherichia coli

Jianfeng Wang, Shiyuan Li, Zhiqiang Xiong and Yong Wang
10.1038/cr.2015.111
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Monocyte-derived Wnt5a regulates inflammatory lymphangiogenesis

Roberto Sessa, Don Yuen, Stephanie Wan, Michael Rosner, Preethi Padmanaban, Shaokui Ge, April Smith, Russell Fletcher, Ariane Baudhuin-Kessel, Terry P Yamaguchi, Richard A Lang and Lu Chen
10.1038/cr.2015.105
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ERRATUM

mTORC2 is a tyrosine kinase

Xuemin Wang and Christopher G Proud
10.1038/cr.2016.18
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