RESEARCH HIGHLIGHTS

In vivo ways to unveil off-targets

Guigen Zhang, Zhuo Zhou and Wensheng Wei
https://doi.org/10.1038/s41422-019-0159-2
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Tissue-resident memory T cells keep cancer dormant

Sarah Sharon Gabrieland Axel Kallies
https://doi.org/10.1038/s41422-019-0156-5
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Linking vitamin B12 and a trembling disorder

Ralph Green and Chadwick W. Christine

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CasX: a new and small CRISPR gene-editing protein

Hui Yang and Dinshaw J. Patel
https://doi.org/10.1038/s41422-019-0165-4
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REVIEWS

The molecular machinery of regulated cell death

Daolin Tang , Rui Kang , Tom Vanden Berghe , Peter Vandenabeele and Guido Kroemer
https://doi.org/10.1038/s41422-019-0164-5
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ORIGINAL ARTICLES

LSECtin on tumor-associated macrophages enhances breast cancer stemness via interaction with its receptor BTN3A3

Di Liu , Qian Lu , Xing Wang , Jun Wang , Ning Lu , Zefei Jiang , Xiaopeng Hao , Jianbin Li , Jing Liu, Pengbo Cao, Guilin Peng,Yuandong Tao , Dianyuan Zhao, Fuchu He and Li Tang
https://doi.org/10.1038/s41422-019-0155-6
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An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis

Junzhong Liu , Lili Feng, Xueting Gu , Xian Deng , Qi Qiu, Qun Li , Yingying Zhang, Muyang Wang , Yiwen Deng, Ertao Wang, Yuke He, Isabel Bäurle , Jianming Li , Xiaofeng Cao and Zuhua He
https://doi.org/10.1038/s41422-019-0145-8
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LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity

Yanyan Wang, Xingrong Du, Jun Wei , Lingyun Long , Haiyan Tan , Cliff Guy , Yogesh Dhungana, Chenxi Qian , Geoffrey Neale, Yang-Xin Fu , Jiyang Yu , Junmin Peng and Hongbo Chi
https://doi.org/10.1038/s41422-019-0157-4
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LKB1 expressed in dendritic cells governs the development and expansion of thymus-derived regulatory T cells

Leonard R. Pelgrom , Thiago A. Patente , Alexey Sergushichev, Ekaterina Esaulova, Frank Otto, Arifa Ozir-Fazalalikhan, Hendrik J. P. van der Zande, Alwin J. van der Ham, Stefan van der Stel, Maxim N. Artyomovand Bart Everts
https://doi.org/10.1038/s41422-019-0161-8
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LETTERS TO THE EDITOR

Neuroendocrine prostate carcinoma cells originate from the p63-expressing basal cells but not the pre-existing adenocarcinoma cells in mice

Dong-Kee Lee, Yonghong Liu , Lan Liao, Wenliang Li, David Danielpourand Jianming Xu
https://doi.org/10.1038/s41422-019-0149-4
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