Advanced Search

Submit Manuscript

Table of Contents

Volume 29 Issue 6, Jun 2019

An old saying from the ancient Chinese philosopher Zhuangzi (Zhuang-Tzu), “A frog in bottom of well doth not imagine sea, whilst an insect in summer doth not interpret ice”, can illustrate that hierarchical activation of AMPK is a matter of space and time. See page 460-473 by Yue Zong et al. for details.

RESEARCH HIGHLIGHTS

How cancers usurp macrophages to keep growing

Olmo Sonzogni and Gerburg M. Wulf
https://doi.org/10.1038/s41422-019-0172-5
Full Text | PDF | Abstract


AMPK hierarchy: a matter of space and time

David Carling

Full Text | PDF | Abstract


Treating leukemia: differentiation therapy for mIDH2 AML

Xiao-Jian Sun , Sai-Juan Chenand Zhu Chen
https://doi.org/10.1038/s41422-019-0173-4
Full Text | PDF | Abstract


LKB1 restrains dendritic cell function

Stefanie K. Wculek and David Sancho
https://doi.org/10.1038/s41422-019-0169-0
Full Text | PDF | Abstract


ORIGINAL ARTICLES

Cortical branched actin determines cell cycle progression

Nicolas Molinie , Svetlana N. Rubtsova , Artem Fokin , Sai P. Visweshwaran , Nathalie Rocques, Anna Polesskaya, Anne Schnitzler, Sophie Vacher, Evgeny V. Denisov , Lubov A. Tashireva , Vladimir M. Perelmuter, Nadezhda V. Cherdyntseva ,Ivan Bièche and Alexis M. Gautreau
https://doi.org/10.1038/s41422-019-0160-9
Full Text | PDF | Abstract | Open Access


Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy

Vera Mugoni , Riccardo Panella , Giulia Cheloni, Ming Chen , Olga Pozdnyakova , Dina Stroopinsky , Jlenia Guarnerio,Emanuele Monteleone , Jonathan David Lee , Lourdes Mendez, Archita Venugopal Menon, Jon Christopher Aster,Andrew A. Lane, Richard Maury Stone, Ilene Galinsky , José Cervera Zamora, Francesco Lo-Coco , Manoj Kumar Bhasin,David Avigan, Letizia Longo, John Gerard Clohessy and Pier Paolo Pandolfi
https://doi.org/10.1038/s41422-019-0162-7
Full Text | PDF | Abstract


Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress

Yue Zong , Chen-Song Zhang , Mengqi Li, Wen Wang , Zhichao Wang , Simon A. Hawley , Teng Ma , Jin-Wei Feng , Xiao Tian,Qu Qi , Yu-Qing Wu, Cixiong Zhang, Zhiyun Ye, Shu-Yong Lin, Hai-Long Piao , D. Grahame Hardie and Sheng-Cai Lin
https://doi.org/10.1038/s41422-019-0163-6
Full Text | PDF | Abstract


Preventing abnormal NF-κB activation and autoimmunity by Otub1-mediated p100 stabilization

Yanchuan Li, Jin-Young Yang, Xiaoping Xie, Zuliang Jie, Lingyun Zhang, Jianhong Shi , Daniel Lin, Meidi Gu, Xiaofei Zhou, Haiyan S. Li , Stephanie S. Watowich , Antrix Jain , Sung Yun Jung , Jun Qin, Xuhong Cheng and Shao-Cong Sun
https://doi.org/10.1038/s41422-019-0174-3
Full Text | PDF | Abstract


Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate

Rui Gao , Xingqun Liang, Sirisha Cheedipudi , Julio Cordero , Xue Jiang, Qingquan Zhang , Luca Caputo , Stefan Günther ,Carsten Kuenne , Yonggang Ren , Shoumo Bhattacharya , Xuejun Yuan, Guillermo Barreto , Yihan Chen , Thomas Braun , Sylvia M. Evans , Yunfu Sun and Gergana Dobreva
https://doi.org/10.1038/s41422-019-0168-1
Full Text | PDF | Abstract | Open Access


LETTERS TO THE EDITOR

Identification of Glutaminyl Cyclase isoenzyme isoQC as a regulator of SIRPα-CD47 axis

Zhiqiang Wu, Linjun Weng, Tengbo Zhang, Hongling Tian,Lan Fang, Hongqi Teng, Wen Zhang, Jing Gao, Yun Hao,Yaxu Li, Hu Zhou and Ping Wang
https://doi.org/10.1038/s41422-019-0177-0
Full Text | PDF | Abstract


CORRIGENDA

Author Correction: 5-Hydroxymethylcytosine signatures incirculating cell-free DNA as diagnostic biomarkers for humancancers

Wenshuai Li, Xu Zhang, Xingyu Lu, Lei You, Yanqun Song, Zhongguang Luo, Jun Zhang, Ji Nie, Wanwei Zheng, Diannan Xu, Yaping Wang, Yuanqiang Dong, Shulin Yu, Jun Hong, Jianping Shi, Hankun Hao, Fen Luo, Luchun Hua, Peng Wang, Xiaoping Qian, Fang Yuan, Lianhuan Wei, Ming Cui, Taiping Zhang, Quan Liao, Menghua Dai, Ziwen Liu, Ge Chen, Katherine Meckel, Sarbani Adhikari, Guifang Jia, Marc B Bissonnette, Xinxiang Zhang, Yupei Zhao, Wei Zhang, Chuan He and Jie Liu
https://doi.org/10.1038/s41422-019-0182-3
Full Text | PDF | Abstract