RESEARCH HIGHLIGHTS

An exercise infusion benefits brain function

Alejandro Pinto, Henriette van Praag
https://doi.org/10.1038/s41422-022-00621-1
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The hens guarding epithelial cancer fox-houses

Liam T. Gaynor, Ramesh A. Shivdasani
https://doi.org/10.1038/s41422-021-00599-2
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How to dodge pyroptosis: lessons from Shigella flexneri

Filip Van Hauwermeiren, Mohamed Lamkanf
https://doi.org/10.1038/s41422-021-00607-5
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Muscularis macrophages: trained guardians of enteric neurons

Maria Francesca Viola, Guy Boeckxstaens
https://doi.org/10.1038/s41422-021-00602-w
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REVIEW ARTICLE

Mechanisms of Polycomb group protein function in cancer

Victoria Parreno, Anne-Marie Martinez, Giacomo Cavalli
https://doi.org/10.1038/s41422-021-00606-6
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ORIGINAL ARTICLES

Pre-ribosomal RNA reorganizes DNA damage repair factors in nucleus during meiotic prophase and DNA damage response

Xiaochen Gai, Di Xin, Duo Wu, Xin Wang, Linlin Chen, Yiqing Wang, Kai Ma, Qilin Li, Peng Li, Xiaochun Yu
https://doi.org/10.1038/s41422-021-00597-4
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A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs

Zezhong Liu, Jie Zhou, Wei Xu, Wei Deng, Yanqun Wang, Meiyu Wang, Qian Wang, Ming Hsieh, Jingming Dong, Xinling Wang, Weijin Huang, Lixiao Xing, Miaoling He, Chunlin Tao, Youhua Xie, Yilong Zhang, Youchun Wang, Jincun Zhao, Zhenghong Yuan, Chuan Qin, Shibo Jiang, Lu Lu
https://doi.org/10.1038/s41422-022-00612-2
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Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate

Ao Hu, Jing-Zan Zhang, Jie Wang, Chen-Chen Li, Meng Yuan, Gang Deng, Zi-Cun Lin, Zhi-Ping Qiu, Hu-Yue Liu, Xian-Wei Wang, Peng-Cheng Wei, Xiao He, Xiaolu Zhao, Wen-Wei Qiu, Bao-Liang Song
https://doi.org/10.1038/s41422-022-00622-0
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Crystal structure and catalytic mechanism of the MbnBC holoenzyme required for methanobactin biosynthesis

Chao Dou, Zhaolin Long, Shoujie Li, Dan Zhou, Ying Jin, Li Zhang, Xuan Zhang, Yanhui Zheng, Lin Li, Xiaofeng Zhu, Zheng Liu, Siyu He, Weizhu Yan, Lulu Yang, Jie Xiong, Xianghui Fu, Shiqian Qi, Haiyan Ren, She Chen, Lunzhi Dai, Binju Wang, Wei Cheng
https://doi.org/10.1038/s41422-022-00620-2
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LETTERS TO THE EDITOR

Loss of Spike N370 glycosylation as an important evolutionary event for the enhanced infectivity of SARS-CoV-2

Shuyuan Zhang, Qingtai Liang, Xinheng He, Chongchong Zhao, Wenlin Ren, Ziqing Yang, Ziyi Wang, Qiang Ding, Haiteng Deng, Tong Wang, Linqi Zhang, Xinquan Wang
https://doi.org/10.1038/s41422-021-00600-y
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Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant of SARS-CoV-2 isolates

Denisa Bojkova, Marek Widera, Sandra Ciesek, Mark N. Wass, Martin Michaelis, Jindrich Cinatl Jr
https://doi.org/10.1038/s41422-022-00619-9
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SARS-CoV-2 Omicron variant is highly sensitive to molnupiravir, nirmatrelvir, and the combination

Pengfei Li, Yining Wang, Marla Lavrijsen, Mart M. Lamers, Annemarie C. de Vries, Robbert J. Rottier, Marco J. Bruno, Maikel P. Peppelenbosch, Bart L. Haagmans, Qiuwei Pan
https://doi.org/10.1038/s41422-022-00618-w
Full Text | PDF | Abstract | Open Access