RESEARCH HIGHLIGHTS

TMED9–SEC12, an important “contact” for autophagy

Claudia Puri, David C. Rubinsztein
https://doi.org/10.1038/s41422-021-00579-6
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It’s just a phase: NLRP6 phase separations drive signaling

Rebecca E. Tweedell, Thirumala-Devi Kanneganti
https://doi.org/10.1038/s41422-021-00594-7
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Disinhibitory feedback loops for reward and aversion

Barbara Juarez, Larry S. Zweifel
https://doi.org/10.1038/s41422-021-00601-x
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SPFH protein cage — one ring to rule them all

Oliver Daumke, Gary R. Lewin
https://doi.org/10.1038/s41422-021-00605-7
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ORIGINAL ARTICLES

A new type of ERGIC–ERES membrane contact mediated by TMED9 and SEC12 is required for autophagosome biogenesis

Shulin Li, Rui Yan, Jialu Xu, Shiqun Zhao, Xinyu Ma, Qiming Sun, Min Zhang, Ying Li, Jun-Jie Gogo Liu, Liangyi Chen, Sai Li, Ke Xu, Liang Ge
https://doi.org/10.1038/s41422-021-00563-0
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A distinct D1-MSN subpopulation down-regulates dopamine to promote negative emotional state

Zhiyuan Liu, Qiumin Le, Yanbo Lv, Xi Chen, Jian Cui, Yiming Zhou, Deqin Cheng, Chaonan Ma, Xiujuan Su, Lei Xiao, Ruyi Yang, Jiayi Zhang, Lan Ma, Xing Liu
https://doi.org/10.1038/s41422-021-00588-5
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An App knock-in rat model for Alzheimer’s disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments

Keliang Pang, Richeng Jiang, Wei Zhang, Zhengyi Yang, Lin-Lin Li, Makoto Shimozawa, Simone Tambaro, Johanna Mayer, Baogui Zhang, Man Li, Jiesi Wang, Hang Liu, Ailing Yang, Xi Chen, Jiazheng Liu, Bengt Winblad, Hua Han, Tianzi Jiang, Weiwen Wang, Per Nilsson, Wei Guo, Bai Lu
https://doi.org/10.1038/s41422-021-00582-x
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Structural insights into the membrane microdomain organization by SPFH family proteins

Chengying Ma, Chengkun Wang, Dingyi Luo, Lu Yan, Wenxian Yang, Ningning Li, Ning Gao
https://doi.org/10.1038/s41422-021-00598-3
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Regulators of tubulin polyglutamylation control nuclear shape and cilium disassembly by balancing microtubule and actin assembly

Lei Wang, Sharad C. Paudyal, Yuchen Kang, Mikito Owa, Feng-Xia Liang, Alexander Spektor, Holger Knaut, Irma Sánchez, Brian D. Dynlacht
https://doi.org/10.1038/s41422-021-00584-9
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LETTERS TO THE EDITOR

Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139

Yali Zhou, Henrik Daver, Boris Trapkov, Lijie Wu, Meng Wu, Kasper Harpsøe, Patrick R. Gentry, Kaiwen Liu, Marina Larionova, Junlin Liu, Na Chen, Hans Bräuner-Osborne, David E. Gloriam, Tian Hua, Zhi-Jie Liu
https://doi.org/10.1038/s41422-021-00591-w
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Structural basis of acyl-CoA transport across the peroxisomal membrane by human ABCD1

Rong Wang, Yu Qin, Xiaochun Li
https://doi.org/10.1038/s41422-021-00585-8
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Structural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3–Gi signaling complexes

Chang Zhao, Lin Cheng, Wei Wang, Heli Wang, Yongbo Luo, Yuying Feng, Xuehui Wang, Hong Fu, Ye Cai, Shengyong Yang, Ping Fu, Wei Yan, Zhenhua Shao
https://doi.org/10.1038/s41422-021-00567-w
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