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Table of Contents

Volume 33 Issue 5, May 2023

The artwork references history by depicting the concept of the Confucian “Doctrine of the Mean”. Tilting vessel, also known as yòu zuò zhī qì, is an ancient Chinese vessel that needs to be filled with an appropriate amount of water to maintain its upright position. Overfilling or underfilling the vessel can render it unstable. Likewise, CAR tonic signaling must be fine-tuned to ensure that it is neither too weak nor too robust, thereby optimizing CAR-T cell fitness. See page 341–354 by Jian Chen et al. for details.

RESEARCH HIGHLIGHTS

Positively charged patches: tonic for CAR fitness

Meraj H. Khan, Jan Joseph Melenhorst
https://doi.org/10.1038/s41422-023-00803-5
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ZBP1 inflames the SARS-CoV-2-infected lung

Chaoran Yin, Siddharth Balachandran
https://doi.org/10.1038/s41422-023-00784-5
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Mitochondrial PD-L1 modulates cancer immunotherapy

Xiaoming Dai, Jing Liu, Wenyi Wei
https://doi.org/10.1038/s41422-023-00777-4
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EMP1+ tumor cells drive metastatic relapse

Oscar E. Villarreal, Scott Kopetz
https://doi.org/10.1038/s41422-022-00769-w
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How pain sensors make the gut weep

Nathalie Stakenborg, Yaping Xue, Guy Boeckxstaens
https://doi.org/10.1038/s41422-022-00768-x
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ORIGINAL ARTICLES

Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness

Jian Chen, Shizhen Qiu, Wentao Li, Kun Wang, Yu Zhang, Han Yang, Baichuan Liu, Guangfei Li, Li Li, Min Chen, Junjie Lan, Jiahua Niu, Peijie He, Lei Cheng, Gaofeng Fan, Xin Liu, Xianmin Song, Chenqi Xu, Haitao Wu, Haopeng Wang
https://doi.org/10.1038/s41422-023-00789-0
Full Text | PDF | Abstract | Open Access


Lysine 2-hydroxyisobutyrylation of NAT10 promotes cancer metastasis in an ac4C-dependent manner

Long Liao, Yan He, Shu-Jun Li, Xiao-Mei Yu, Zhi-Chao Liu, Yi-Yao Liang, Han Yang, Jing Yang, Guo-Geng Zhang, Chun-Miao Deng, Xian Wei, Yi-Dong Zhu, Tao-Yang Xu, Can-Can Zheng, Chao Cheng, Ang Li, Zhi-Gang Li, Jin-Bao Liu, Bin Li
https://doi.org/10.1038/s41422-023-00793-4
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A lncRNA from an inflammatory bowel disease risk locus maintains intestinal host-commensal homeostasis

Hongdi Ma, Taidou Hu, Wanyin Tao, Jiyu Tong, Zili Han, Dietmar Herndler-Brandstetter, Zheng Wei, Ruize Liu, Tingyue Zhou, Qiuyuan Liu, Xuemei Xu, Kaiguang Zhang, Rongbin Zhou, Judy H. Cho, Hua-Bing Li, Hailiang Huang, Richard A. Flavell, Shu Zhu
https://doi.org/10.1038/s41422-023-00790-7
Full Text | PDF | Abstract | Open Access


Subtyping-based platform guides precision medicine for heavily pretreated metastatic triple-negative breast cancer: The FUTURE phase II umbrella clinical trial

Yin Liu, Xiu-Zhi Zhu, Yi Xiao, Song-Yang Wu, Wen-Jia Zuo, Qiang Yu, A-Yong Cao, Jun-Jie Li, Ke-Da Yu, Guang-Yu Liu, Jiong Wu, Tao Sun, Jiu-Wei Cui, Zheng Lv, Hui-Ping Li, Xiao-Yu Zhu, Yi-Zhou Jiang, Zhong-Hua Wang, Zhi-Ming Shao
https://doi.org/10.1038/s41422-023-00795-2
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LETTERS TO THE EDITOR

H3K4me2/3 modulate the stability of RNA polymerase II pausing

Shibin Hu, Aixia Song, Linna Peng, Nan Tang, Zhibin Qiao, Zhenning Wang, Fei Lan, Fei Xavier Chen
https://doi.org/10.1038/s41422-023-00794-3
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Polyvalent mRNA vaccination elicited potent immune response to monkeypox virus surface antigens

Zhenhao Fang, Valter S. Monteiro, Paul A. Renauer1, Xingbo Shang, Kazushi Suzuki, Xinyu Ling, Meizhu Bai, Yan Xiang, Andre Levchenko, Carmen J. Booth, Carolina Lucas, Sidi Chen
https://doi.org/10.1038/s41422-023-00792-5
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