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Table of Contents

Volume 33 Issue 4, Apr 2023

The image shows a Chinese fairy tale, the “Blue Bird as a messenger”, wherein Blue Bird delivers messages for Xiwangmu (the Immortal Queen Mother). The Blue Bird is reminiscent of famsin, a novel gut-secreted hormone, which mediates communication between the intestine and other organs to promote metabolic adaptations to fasting and enhance animal survival when food is scarce. See page 273–287 by Aijun Long et al. for details.

RESEARCH HIGHLIGHTS

cGASing mitochondria to fend off ferroptosis

Hua Wan, Xuejun Jiang
https://doi.org/10.1038/s41422-023-00791-6
Full Text | PDF | Abstract


Crank up the volume: Osmotic stress induces WNK1 phase separation

Ji-Ung Jung, Clinton A. Taylor IV, Melanie H. Cobb
https://doi.org/10.1038/s41422-022-00763-2
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Life mimics art

Muthukumaran Venkatachalapathy, Craig M. Crews
https://doi.org/10.1038/s41422-022-00765-0
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Transcription initiation by the ERRs: no ligand but two activation pathways

Vincent Giguère
https://doi.org/10.1038/s41422-023-00780-9
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tRNA-m1A modification: a translational checkpoint for T cell expansion

Weike Pei, Vijay K. Kuchroo
https://doi.org/10.1038/s41422-022-00764-1
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ORIGINAL ARTICLES

Famsin, a novel gut-secreted hormone, contributes to metabolic adaptations to fasting via binding to its receptor OLFR796

Aijun Long, Yang Liu, Xinlei Fang, Liangjie Jia, Zhiyuan Li, Jiang Hu, Shuang Wu, Chao Chen, Ping Huang, Yiguo Wang
https://doi.org/10.1038/s41422-023-00782-7
Full Text | PDF | Abstract


Human IFT-A complex structures provide molecular insights into ciliary transport

Meiqin Jiang, Vivek Reddy Palicharla, Darcie Miller, Sun-Hee Hwang, Hanwen Zhu, Patricia Hixson, Saikat Mukhopadhyay, Ji Sun
https://doi.org/10.1038/s41422-023-00778-3
Full Text | PDF | Abstract | Open Access


Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression

Shiqiao Qiu, Xiuying Zhong, Xiang Meng, Shiting Li, Xiaoyu Qian, Hui Lu, Jin Cai, Yi Zhang, Mingjie Wang, Zijian Ye, Huafeng Zhang, Ping Gao
https://doi.org/10.1038/s41422-023-00788-1
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Mechanism of activation and biased signaling in complement receptor C5aR1

Yuying Feng, Chang Zhao, Yue Deng, Heli Wang, Liang Ma, Sicen Liu, Xiaowen Tian, Bo Wan, Yan Bin, Peipei Chen, Wei Yan, Ping Fu, Zhenhua Shao
https://doi.org/10.1038/s41422-023-00779-2
Full Text | PDF | Abstract | Open Access


LETTERS TO THE EDITOR

Aspirin protects against genotoxicity by promoting genome repair

Hui Jiang, Patrycja Swacha, Kyaw Min Aung, Nelson O Gekara
https://doi.org/10.1038/s41422-023-00783-6
Full Text | PDF | Abstract | Open Access


Structural basis of sRNA RsmZ regulation of Pseudomonas aeruginosa virulence

Xinyu Jia, Zhiling Pan, Yang Yuan, Bingnan Luo, Yongbo Luo, Sunandan Mukherjee, Guowen Jia, Liu Liu, Xiaobin Ling, Xiting Yang, Zhichao Miao, Xiawei Wei, Janusz M. Bujnicki, Kelei Zhao, Zhaoming Su
https://doi.org/10.1038/s41422-023-00786-3
Full Text | PDF | Abstract