Cell Research

Volume 35 Issue 3, Mar 2025

This image symbolizes the identification of the noncanonical proteome, where scattered glimmers of light (peptides) converge to form a radiant lamp (proteome). The quest to uncover noncanonical proteins is likened to seeking a flicker of firelight in the darkness. In this study, a hidden peptidome has been unearthed and transformed into a radiant beacon, illuminating uncharted pathways for future proteomic research. See page 186–204 by Chengyu Shi et al. for details.

RESEARCH HIGHLIGHTS

H_₂O_₂ regulates rice defense via bHLH25 oxidation

Lijun Cao, Xinnian Dong
https://doi.org/10.1038/s41422-025-01071-1
Full Text | PDF | Abstract

The non-canonical proteome: a novel contributor to cancer proliferation

Jorge Ruiz-Orera, Norbert Hübner
https://doi.org/10.1038/s41422-024-01069-1
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Halt aging? — functional HSCs lead the way

Rebecca T. Chu, Adam B. Schroer, Saul A. Villeda
https://doi.org/10.1038/s41422-025-01079-7
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Metabolite is a part of immune-regulating circuit

Han Wang, Shi-Min Zhao
https://doi.org/10.1038/s41422-025-01074-y
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Fine-tuning protein hunger: sex- and mating-dependent setpoint control

Yangkyun Oh, Won-Jae Lee
https://doi.org/10.1038/s41422-024-01039-7
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Nucleophagy repairs toxic DNA lesions

Ines Tomaskovic, Cristian Prieto-Garcia, Ivan Dikic
https://doi.org/10.1038/s41422-024-01043-x
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ORIGINAL ARTICLES

Raptin, a sleep-induced hypothalamic hormone, suppresses appetite and obesity

Ling-Qi Xie, Biao Hu, Ren-Bin Lu, Ya-Lun Cheng, Xin Chen, Jie Wen, Yao Xiao, Yu-Ze An, Ning Peng, Yu Dai, Genqing Xie, Qi Guo, Hui Peng, Xiang-Hang Luo
https://doi.org/10.1038/s41422-025-01078-8
Full Text | PDF | Abstract | Open Access

Comprehensive discovery and functional characterization of the noncanonical proteome

Chengyu Shi, Fangzhou Liu, Xinwan Su, Zuozhen Yang, Ying Wang, Shanshan Xie, Shaofang Xie, Qiang Sun, Yu Chen, Lingjie Sang, Manman Tan, Linyu Zhu, Kai Lei, Junhong Li, Jiecheng Yang, Zerui Gao, Meng Yu, Xinyi Wang, Junfeng Wang, Jing Chen, Wei Zhuo, Zhaoyuan Fang, Jian Liu, Qingfeng Yan, Dante Neculai, Qiming Sun, Jianzhong Shao, Weiqiang Lin, Wei Liu, Jian Chen, Liangjing Wang, Yang Liu, Xu Li, Tianhua Zhou, Aifu Lin
https://doi.org/10.1038/s41422-024-01059-3
Full Text | PDF | Abstract | Open Access

Rice transcription factor bHLH25 confers resistance to multiple diseases by sensing H₂O₂

Haicheng Liao, Yu Fang, Junjie Yin, Min He, Yingjie Wei, Juan Zhang, Shuang Yong, Jiankui Cha, Li Song, Xiaobo Zhu, Xixi Chen, Ján Kováč, Qingqing Hou, Zhaotang Ma, Xiaogang Zhou, Lin Chen, Emi Yumoto, Tian Yang, Qi He, Wei Li, Yixin Deng, Haoxuan Li, Mingwu Li, Hai Qing, Lijuan Zou, Yu Bi, Jiali Liu, Yihua Yang, Daihua Ye, Qi Tao, Long Wang, Qing Xiong, Xiang Lu, Yongyan Tang, Ting Li, Bingtian Ma, Peng Qin, Yan Li, Wenming Wang, Yangwen Qian, Jaroslav Ďurkovič, Koji Miyamoto, Mawsheng Chern, Shigui Li, Weitao Li, Jing Wang, Xuewei Chen
https://doi.org/10.1038/s41422-024-01058-4
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LETTERS TO THE EDITOR

Fourth-generation chimeric antigen receptor T-cell therapy is tolerable and efficacious in treatment-resistant rheumatoid arthritis

Yujing Li, Sujun Li, Xiaojuan Zhao, Jun Sheng, Lei Xue, Georg Schett, Ce Shi, Biliang Hu, Xingbing Wang, Zhu Chen
https://doi.org/10.1038/s41422-024-01068-2
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Heat acclimation in mice requires preoptic BDNF neurons and postsynaptic potentiation

Baoting Chen, Cuicui Gao, Changhao Liu, Tongtong Guo, Junwei Hu, Jialiang Xue, Kangmin Tang, Yuelai Chen, Tian Yu, Qiwei Shen, Hongbin Sun, Wen Z. Yang, Wei L. Shen
https://doi.org/10.1038/s41422-024-01064-6
Full Text | PDF | Abstract | Open Access