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Table of Contents

Volume 35 Issue 2, Feb 2025

The old Chinese philosophical concept states, “The Tai Chi gives rise to the Two Forms (Yin and Yang), which generate the Four Symbols (Si Xiang)”. The positive (Yang) and negative (Yin) regulations of the immune system drive different patterns of immune homeostasis. For example, RelA-TTP-GLO2-SLG functions as the Four Symbols, which are mutually regulated, ensuring precise control of the immune system to prevent excessive inflammation and tissue damage. See page 97–116 by Qihang Zhao et al. for details.

RESEARCH HIGHLIGHTS

Neurotensin signaling in fat modulates food intake

YoungUk Jang, Prashant Rajbhandari
https://doi.org/10.1038/s41422-024-01048-6
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Intrathymic alloantigen expression—the Holy Grail or reinventing the wheel?

Gavin J. Pettigrew
https://doi.org/10.1038/s41422-024-01067-3
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Knowing when to stop: MICL self-regulates neutrophil NETosis

Hanjoo Brian Shim, Justin François Deniset, Paul Kubes
https://doi.org/10.1038/s41422-024-01037-9
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Stroke-induced trained immunity spells bad news for the heart

George Hajishengallis, Triantafyllos Chavakis
https://doi.org/10.1038/s41422-024-01018-y
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Preservation of a youthful path to evergreen platelets?

Sten Eirik W. Jacobsen
https://doi.org/10.1038/s41422-024-01015-1
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PDK1 neddylation by Smurf1 drives Akt activation

Rajesh Kumar Manne, Rajni Kant, Hui-Kuan Lin
https://doi.org/10.1038/s41422-024-01020-4
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ORIGINAL ARTICLES

Nonenzymatic lysine d-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses

Qihang Zhao, Qiang Wang, Qinghua Yao, Zhengdong Yang, Wenfang Li, Xiaojie Cheng, Yingling Wen, Rong Chen, Junfang Xu, Xuanying Wang, Dexiang Qin, Shuyang Zhu, Liujie He, Nan Li, Yanfeng Wu, Yizhi Yu, Xuetao Cao, Pin Wang
https://doi.org/10.1038/s41422-024-01060-w
Full Text | PDF | Abstract | Open Access


Neurotensin-neurotensin receptor 2 signaling in adipocytes suppresses food intake through regulating ceramide metabolism

Wei Fu, Yuanting Lai, Kexin Li, Yue Yang, Xiao Guo, Qifan Gong, Xiaofeng Zhou, Liying Zhou, Cenxi Liu, Zhi Zhang, Jisun So, Yufeng Zhang, Lin Huang, Guangxing Lu, Chuanyou Yi, Qichu Wang, Chenyu Fan, Chao Liu, Jiaxing Wang, Haiyi Yu, Yimin Zhao, Tao Huang, Hyun Cheol Roh, Tiemin Liu, Huiru Tang, Jianping Qi, Ming Xu, Yan Zheng, He Huang, Jin Li
https://doi.org/10.1038/s41422-024-01038-8
Full Text | PDF | Abstract | Open Access


Donor MHC-specific thymus vaccination allows for immunocompatible allotransplantation

Yang Liu, Hexi Feng, Ke Li, Ruiyi Li, Xiao-Jie Zhang, Ye Tian, Yujiang Fang, Yanjie Zhou, Ling Liu, Xiaoqing Zhang
https://doi.org/10.1038/s41422-024-01049-5
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LETTERS TO THE EDITOR

Structure and genome editing activity of the novel CRISPR-Cas12o1 effector

Zhiqiang Duan, Xi Zhang, Jun-Tao Zhang, Xingkun Ji, Ruiheng Liu, Ying Chen, Shanshan Li, Nannan Jia, Huizhi Gao, Yu Xin, Ning Jia, Jian-Kang Zhu
https://doi.org/10.1038/s41422-024-01050-y
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Photoactivated SOPP3 enables APEX2-mediated proximity labeling with high spatio-temporal resolution in live cells

Dajun Qu, Yaxin Li, Qian Liu, Biao Cao, Mengye Cao, Xiaoxi Lin, Chengxing Shen, Peng Zou, Hu Zhou, Wenjuan Zhang, Weijun Pan
https://doi.org/10.1038/s41422-024-01061-9
Full Text | PDF | Abstract | Open Access