EDITORIAL

Sanofi-Cell Research outstanding paper award of 2024

https://doi.org/10.1038/s41422-025-01201-9
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RESEARCH HIGHLIGHTS

KCNQ1 and PIP₂: it takes two to tango

Alicia De La Cruz, H. Peter Larsson
https://doi.org/10.1038/s41422-025-01189-2
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CNS gatekeepers: IFNγ-activated dendritic cells control leptomeningeal metastasis

Alberto Hernández-Barranco, Johanna A. Joyce
https://doi.org/10.1038/s41422-025-01144-1
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Gut microbiota fuels clonal hematopoiesis

Francisco Caiado, Markus G. Manz
https://doi.org/10.1038/s41422-025-01137-0
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Psychedelics target neuroimmune interactions to limit fear

Johana Alvarez, Scott J. Russo

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Too sweet to be savory: how fructose elicits microglia-driven disturbance of neurodevelopment

Maximilian Fliegauf, Marco Prinz
https://doi.org/10.1038/s41422-025-01148-x
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Antibiotics deliver a gut punch to infant immunity

Brian D. Rudd
https://doi.org/10.1038/s41422-025-01158-9
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ORIGINAL ARTICLES

Glucose starvation mimetic aldometanib removes immune barriers permitting mice with hepatocellular carcinoma to live to normal ages

Hui-Hui Hu, Xuefeng Wang, Bin Lan, Haili Cheng, Hong Wen, Fangfang Chen, Jianfeng Wu, Mengqi Li, Jiazhou Chen, Jinhui Zhang, Dongxu Chen, Shiyu Lin, Jieyu Lin, Mingyang Yang, Zhenhua Wu, Zhong-Zheng Zheng, Fuqing Chen, Jianyin Zhou, Gang Chen, Yu Chen, Xianming Deng, Chen-Song Zhang, Jingfeng Liu, Sheng-Cai Lin
https://doi.org/10.1038/s41422-025-01195-4
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Modeling post-gastrula development via bidirectional pluripotent stem cells

Kuisheng Liu, Zihui Yan, Dandan Bai, Rui Jiang, Yan Bi, Xiangjun Ma, Jiani Xiang, Yifan Sheng, Baoxing Dong, Zhiyuan Ning, Shanru Yi, Yingdong Liu, Xinyi Lei, Yanping Jia, Yan Zhang, Yalin Zhang, Yanhe Li, Tao Wu, Chenxiang Xi, Shanyao Liu, Shuyi Liu, Jiayu Chen, Jiqing Yin, Xiaochen Kou, Yanhong Zhao, Hong Wang, Yixuan Wang, Ke Wei, Shaorong Gao, Wenqiang Liu
https://doi.org/10.1038/s41422-025-01172-x
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Harnessing alternative splicing for off-the-shelf mRNA neoantigen vaccines in hepatocellular carcinoma

Haichao Zhao, Yifei Cheng, Tiancheng Zhang, Qianxi Wang, Yanan Xu, Ganggang Wang, Yuanli Song, Hang Chen, Yingcheng Wu, Mao Zhang, Youpei Lin, Changyou Zhan, Jia Fan, Qiang Gao
https://doi.org/10.1038/s41422-025-01199-0
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Targeted destruction of VISTA boosts anti-tumor immunotherapy

Li Chen, Xia Bu, Yishuang Sun, Daoyuan Huang, Yong Chen, Tao Hou, Xiaoping Hu, Jingchao Wang, Peiqiang Yan, Yihang Qi, Weiwei Jiang, Yan Xiong, Jing Liu, Yang Gao, Mengxi Huan, Bin Wang, Qianjia Liu, Xiaoming Dai, Fabin Dang, John M. Asara, Masanori Fujimoto, Hiroyuki Inuzuka, Jian Jin, Jinfang Zhang, Gordon J. Freeman, Wenyi Wei
https://doi.org/10.1038/s41422-025-01194-5
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Destruction of VISTA by TRIM25 ablation in T cells potentiates cancer immunotherapy

Yishuang Sun, Zijian Zhang, Haiou Li, Xia Bu, Li Chen, Xiyong Wang, Lifang Fan, Baoxiang Chen, Lijun Kong, Panpan Dai, Wenjing Song, Xiangling Xiao, Jie Shi, Bolin Xiang, Chuan He, Yingmeng Yao, Wenjun Xiong, Haisheng Yu, Congqing Jiang, Qun Qian, Hudan Liu, Sufang Tian, Guoliang Qing, Zhiyong Yang, Wenyi Wei, Gordon J. Freeman, Haichuan Zhu, Jinfang Zhang
https://doi.org/10.1038/s41422-025-01186-5
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The molecular basis of μ-opioid receptor signaling plasticity

Huibing Zhang, Xueting Wang, Kun Xi, Qingya Shen, Jianheng Xue, Yanqing Zhu, Shao-Kun Zang, Tianqiang Yu, Dan-Dan Shen, Jia Guo, Li-Nan Chen, Su-Yu Ji, Jiao Qin, Yingjun Dong, Mingming Zhao, Ming Yang, Haijing Wu, Guoli Yang, Yan Zhang
https://doi.org/10.1038/s41422-025-01191-8
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Genomic and transcriptomic dynamics in the stepwise progression of lung adenocarcinoma

Fangqiu Fu, Jun Shang, Yueren Yan, He Jiang, Han Han, Hui Yuan, Zhendong Gao, Jingcheng Yang, Jian Gao, Jun Wang, Yunjian Pan, Yicong Lin, Ting Ye, Yiliang Zhang, Yawei Zhang, Jiaqing Xiang, Hong Hu, Zhiwei Cao, Yuanting Zheng, Yuan Li, Yang Zhang, Li Jin, Leming Shi, Haiquan Chen
https://doi.org/10.1038/s41422-025-01200-w
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Activation of the SPARDA defense system by filament assembly using a beta-relay signaling mechanism widespread in prokaryotic Argonautes

Edvinas Jurgelaitis, Evelina Zagorskaitė, Aurimas Kopūstas, Simonas Asmontas, Elena Manakova, Indrė Dalgėdienė, Ugnė Tylenytė, Arunas Silanskas, Paulius Toliusis, Algirdas Grybauskas, Marijonas Tutkus, Česlovas Venclovas, Mindaugas Zaremba
https://doi.org/10.1038/s41422-025-01198-1
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LETTERS TO THE EDITOR

Nearly complete redirection of insertion-type indel into recombination enhances knock-in and facilitates endogenous biomolecular condensate analysis

Minglei Huang, Jingjing Fu, Peizhe Wang, Boyi Chen, Qichen Yuan, Jiawei Yu, Huimin Wang, Yiting Liu, Zhiyi Li, Yanling Wu, Tianlei Ying, Qingfeng Wu, Ming Zhu, Wei Qin, Yinqing Li
https://doi.org/10.1038/s41422-025-01190-9
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