RESEARCH HIGHLIGHTS

SMAD5 signaling: more than meets the nuclei

John Orlowski
10.1038/cr.2017.101
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An mRNA-based vaccine strategy against Zika

Gary Wong and George F Gao
10.1038/cr.2017.53
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Threading an elephant through the eye of a needle: Where are platelets made?

Ian Johnston, Vincent Hayes and Mortimer Poncz
10.1038/cr.2017.65
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RIPped for neuroinflammation

Bart Tummers and Douglas R Green
10.1038/cr.2017.75
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ORIGINAL ARTICLES

Smad5 acts as an intracellular pH messenger and maintains bioenergetic homeostasis

Yujiang Fang, Zhongliang Liu, Zhenyu Chen, Xiangjie Xu, Mengtao Xiao, Yanyan Yu, Yuanyuan Zhang, Xiaobai Zhang, Yanhua Du, Cizhong Jiang, Yuzheng Zhao, Yiran Wang, Beibei Fan, Daniel Terheyden-Keighley, Yang Liu, Lei Shi, Yi Hui, Xin Zhang, Bowen Zhang, Hexi Feng, Lin Ma, Quanbin Zhang, Guohua Jin, Yi Yang, Bin Xiang, Ling Liu and Xiaoqing Zhang
10.1038/cr.2017.85
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Mettl3-mediated m6A regulates spermatogonial differentiation and meiosis initiation

Kai Xu, Ying Yang, Gui-Hai Feng, Bao-Fa Sun, Jun-Qing Chen, Yu-Fei Li, Yu-Sheng Chen, Xin-Xin Zhang, Chen-Xin Wang, Li-Yuan Jiang, Chao Liu, Ze-Yu Zhang, Xiu-Jie Wang, Qi Zhou, Yun-Gui Yang and Wei Li
10.1038/cr.2017.100
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Ythdc2 is an N⁶-methyladenosine binding protein that regulates mammalian spermatogenesis

Phillip J Hsu, Yunfei Zhu, Honghui Ma, Yueshuai Guo, Xiaodan Shi, Yuanyuan Liu, Meijie Qi, Zhike Lu, Hailing Shi, Jianying Wang, Yiwei Cheng, Guanzheng Luo, Qing Dai, Mingxi Liu, Xuejiang Guo, Jiahao Sha, Bin Shen and Chuan He
10.1038/cr.2017.99
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IPA1 functions as a downstream transcription factor repressed by D53 in strigolactone signaling in rice

Xiaoguang Song, Zefu Lu, Hong Yu, Gaoneng Shao, Jinsong Xiong, Xiangbing Meng, Yanhui Jing, Guifu Liu, Guosheng Xiong, Jingbo Duan, Xue-Feng Yao, Chun-Ming Liu, Hongqing Li, Yonghong Wang and Jiayang Li
10.1038/cr.2017.102
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Non-canonical regulation of SPL transcription factors by a human OTUB1-like deubiquitinase defines a new plant type rice associated with higher grain yield

Shuansuo Wang, Kun Wu, Qian Qian, Qian Liu, Qi Li, Yajun Pan, Yafeng Ye, Xueying Liu, Jing Wang, Jianqing Zhang, Shan Li, Yuejin Wu and Xiangdong Fu
10.1038/cr.2017.98
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Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium

Hui Zhang, Xiuzhen Huang, Kuo Liu, Juan Tang, Lingjuan He, Wenjuan Pu, Qiaozhen Liu1,2, Yan Li, Xueying Tian, Yue Wang, Libo Zhang, Ying Yu, Hongyan Wang, Ronggui Hu, Fengchao Wang, Ting Chen, Qing-Dong Wang, Zengyong Qiao, Li Zhang, Kathy O Lui8 and Bin Zhou
10.1038/cr.2017.10
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LETTERS TO THE EDITOR

Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding

Jiping Yang, Jingyi Li, Keiichiro Suzuki, Xiaomeng Liu, Jun Wu, Weiqi Zhang, Ruotong Ren, Weizhou Zhang, Piu Chan, Juan Carlos Izpisua Belmonte, Jing Qu, Fuchou Tang and Guang-Hui Liu
10.1038/cr.2017.86
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Receptor-like protein ELT1 promotes brassinosteroid signaling through interacting with and suppressing the endocytosis-mediated degradation of receptor BRI1

Bao-Jun Yang, Wen-Hui Lin, Fang-Fang Fu, Zhi-Hong Xu and Hong-Wei Xue
10.1038/cr.2017.69
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