RESEARCH HIGHLIGHTS

eRNAs reach the heart of transcription

Carlos A Melo, Nicolas Léveillé and Reuven Agami
10.1038/cr.2013.97
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Directing transcription to the right way

Fu Huang and Jerry L Workman
10.1038/cr.2013.100
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Pills of PTEN? In and out for tumor suppression

Antonella Papa, Ming Chen and Pier Paolo Pandolfi
10.1038/cr.2013.103
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EGFR gets in the way of microRNA biogenesis

Naohiro Nishida, Koshi Mimori, Masaki Mori and George A Calin
10.1038/cr.2013.87
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New hope for therapy in neurodegenerative diseases

Maria do Carmo Costa and Henry L Paulson
10.1038/cr.2013.96
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The Years of the Monkey

Xiaojun Lian1 and Kenneth R Chien1
10.1038/cr.2013.111
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ORIGINAL ARTICLES

Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system

Albert W Cheng, Haoyi Wang, Hui Yang, Linyu Shi, Yarden Katz, Thorold W Theunissen, Sudharshan Rangarajan, Chikdu S Shivalila, Daniel B Dadon and Rudolf Jaenisch
10.1038/cr.2013.122
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Driving vascular endothelial cell fate of human multipotent Isl1+ heart progenitors with VEGF modified mRNA

Kathy O Lui1,2,3,*, Lior Zangi, Eduardo A Silva, Lei Bu, Makoto Sahara, Ronald A Li, David J Mooney and Kenneth R Chien
10.1038/cr.2013.112
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Generation of haploid embryonic stem cells from Macaca fascicularis monkey parthenotes

Hui Yang, Zhen Liu, Yu Ma, Cuiqing Zhong, Qi Yin, Chikai Zhou, Linyu Shi, Yijun Cai, Hanzhi Zhao, Hui Wang, Fan Tang, Yan Wang, Chenchen Zhang, Xin-yuan Liu, Dongmei Lai, Ying Jin, Qiang Sun and Jinsong Li
10.1038/cr.2013.93
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A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity

Tong Guo, Yi Lu, Peixue Li, Meng-Xin Yin, Dekang Lv, Wenjing Zhang, Huizhen Wang, Zhaocai Zhou, Hongbin Ji, Yun Zhao and Lei Zhang
10.1038/cr.2013.120
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Structure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage response

Yucai Wang, Xiao Han, Fangming Wu, Justin W Leung, Megan G Lowery, Huong Do, Junjie Chen, Chaowei Shi, Changlin Tian, Lei Li and Weimin Gong
10.1038/cr.2013.124
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LETTERS TO THE EDITOR

Efficient genome editing in plants using a CRISPR/Cas system

Zhengyan Feng, Botao Zhang, Wona Ding, Xiaodong Liu, Dong-Lei Yang, Pengliang Wei, Fengqiu Cao, Shihua Zhu, Feng Zhang, Yanfei Mao and Jian-Kang Zhu
10.1038/cr.2013.114
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Targeted mutagenesis in rice using CRISPR-Cas system

Jin Miao, Dongshu Guo, Jinzhe Zhang, Qingpei Huang, Genji Qin, Xin Zhang, Jianmin Wan, Hongya Gu and Li-Jia Qu
10.1038/cr.2013.123
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Coordinated regulation of AMPK activity by multiple elements in the α-subunit

Feng-Jiao Xin, Jue Wang, Rong-Qing Zhao, Zhi-Xin Wang and Jia-Wei Wu
10.1038/cr.2013.121
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